squamous intraepithelial lesion

Cytology A term that encompasseses a spectrum of noninvasive cervical epithelial abnormalities–eg, flat condyloma, dysplasia/carcinoma in situ, CIN; the Bethesda Classification divides SILs into low-grade and high-grade lesions; the former encompass cellular changes associated with HPV cytopathic effect–koilocytotic atypia and mild dysplasia; high-grade lesions encompass moderate dysplasia, severe dysplasia, carcinoma in situ/CIN2–3. See CIN, High-grade squamous intraepithelial lesion, Low-grade squamous intraepithelial lesion, Pap smear.

Squamous intraepithelial lesion (SIL)

A term used to categorize the severity of abnormal changes arising in the squamous, or outermost, layer of the cervix.

Mentioned in: Cervical Cancer, Pap Test

Mentioned in

References in periodicals archive

Using a low threshold reference standard of cytology diagnosed squamous intraepithelial lesion and the HIV status of the women masked, VIA and VILI had similar test characteristics except for the PPV in which VIA value of 91.5% was significantly higher than 77.7% for VILI (p=0.01).

Evaluation of direct visual inspection of the cervix in detecting cytology diagnosed squamous intraepithelial lesion in women of known HIV status. A randomized trial (CANHIV study)

Incidence of cervical squamous intraepithelial lesions in HIV-infected women.

South African women with cervical cancer often present late and have a poor prognosis as a result

Infection with the human immunodeficiency virus (HIV) and its related immunosuppression are associated with an increased risk of prevalence, incidence, and persistent squamous intraepithelial lesions (SILs) of the cervix (2, 3).

Epidemiology of cervical squamous intraepithelial lesions in HIV infected women in Kenya: a cross-sectional study

Among the positive findings were 12 cases of atypical squamous cells of undetermined significance (5.2%), 28 low-grade squamous intraepithelial lesions (12%), 1 high-grade squamous intraepithelial lesion (0.4%) and 2 cases of cancer (0.9%).

Sensitivity and specificity of the human papillomavirus identification test

This 2-year prospective study examined a subpopulation of 1539 women from the ASCUS/LSIL (atypical squamous cells of uncertain significance)/Bow-grade squamous intraepithelial lesion) Triage Study (ALTS) to determine the ideal follow-up strategy for women diagnosed with CIN1 or HPV effect on colposcopic biopsy-obtained histology.

What is the appropriate management for a patient with CIN1 on colposcopy?

A review and update on papillary immature metaplasia of the uterine cervix: a distinct subset of low-grade squamous intraepithelial lesion, proposing a possible cell of origin.

Papillary Immature Metaplasia and Thin High-Grade Squamous Intraepithelial Lesion Originate in Early Metaplastic Epithelium of the Cervix

Caption: Figure 1: (a) Atypical cells of undetermined significance, (b) low-grade squamous intraepithelial lesion, (c) high-grade squamous intraepithelial lesion, (d) squamous cell carcinoma, (e) changes of herpes simplex virus, and (f) human papillomavirus--koilocytic changes

Study of cytodiagnosis of discharge per vaginum with specific reference to human papilloma virus and herpes simplex virus at tertiary care center, indore

34 cases (5.63%) showed squamous intraepithelial lesion (SIL).

A clinicopathological study on cervix

Since women with cytology results of low-grade squamous intraepithelial lesion (LSIL) progress to CIN 2 or 3 in the same proportion, management protocols for HPV-positive ASCUS and LSIL should be identical.

Which cytology results predict cervical intraepithelial neoplasia?

In our cytopathology laboratory, the specimens are prepared via ThinPrep methodology (Cytyc) and interpreted by using the Bethesda system terminology as unsatisfactory; benign; ASC-US; low-grade squamous intraepithelial lesion (LSIL); atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H); HSIL; and squamous cell carcinoma (SCC).

Anal Cytology: Institutional Statistics, Correlation With Histology, and Development of Multidisciplinary Screening Program With Review of the Current Literature

Atypical Squamous cells cannot exclude a HSIL (ASC-H) (n=24/0.19%), Low Grade Squamous Intraepithelial Lesion (LSIL) (n=172/1.35%), High Grade Squamous Intraepithelial Lesion (HSIL) (n=91/17.3%) Squamous cell carcinoma (n=21/0.17%) Atypical Glandular Cells (AGC-NOS) (n=53/0.42%) Atypical Glandular Cells--favor neoplastic (n=23/0.18%) Endocervical adenocarcinoma in situ (n=01/ 0.01%) Endocervical adenocarcinoma (n=01/0.01%) Endometrial adenocarcinoma (n=19/0.15%).

The spectrum of cervical cytological abnormalities in Kuwait using the revised 2001 Bethesda system