dyskaryosis

[dis″kar-e-o´sis]

abnormality of the nucleus of a cell. adj., adj dyskaryot´ic.

dys·kar·y·o·sis

(dis'kar-ē-ō'sis),

Abnormal maturation seen in exfoliated cells that have normal cytoplasm but hyperchromatic nuclei, or irregular chromatin distribution; may be followed by the development of a malignant neoplasm.

[dys- + G. karyon, nucleus, + -ōsis, condition]

Farlex Partner Medical Dictionary © Farlex 2012

dyskaryosis

A UK term for premalignant and malignant nuclear abnormalities in epithelial cells seen in cervical specimens.

Mild dyskaryosis—Low-grade squamous intraepithelial lesion.
Moderate dyskaryosis—High-grade squamous intraepithelial lesion.
Severe dyskaryosis—High-grade squamous intraepithelial lesion.

dys·kar·y·o·sis

(dis-kar'ē-ō'sis)

Abnormal maturation seen in exfoliated cells that have normal cytoplasm but hyperchromatic nuclei, or irregular chromatin distribution; may be followed by the development of a malignant neoplasm.

[dys- + G. karyon, nucleus, + -ōsis, condition]

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

dyskaryosis

A visible abnormality in the nuclei of cells that appear otherwise normal. Dyskaryosis is a minimal change seen, for instance, in cells scraped from the surface of the cervix in a PAP SMEAR test and does not necessarily imply any worrying abnormality.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

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References in periodicals archive

Kitchener et al., "Mild and moderate dyskaryosis: can women be selected for colposcopy on the basis of social criteria?" British Medical Journal, vol.

Standardized Digital Colposcopy with Dynamic Spectral Imaging for Conservative Patient Management

We corrected the diagnosis to BPH because there were no findings suggesting prostate cancer such as nuclear enlargement and dyskaryosis in the epithelial cells.

Prostatic Stromal Tumor of Uncertain Malignant Potential Which Was Difficult to Diagnose

Figures 1-3 show smears with the dyskaryosis phenomenon.

Cytological study of vaginal smears of women of fertility age in the screening population

A vaginal cytology test by the TCT method showed dyskaryosis with grade III high-grade squamous vaginal intraepithelial neoplasia (Fig.1D).

Post-hysterectomy vaginal cuff cancer secondary to HPV infection and CIN

The correlation between grade of dyskaryosis on cervicalsmear, grade of cervical intraepithelial neoplasia (CIN) on punch biopsy and the final histologic diagnosis on cone biopsies of the cervix.

Quality improvement opportunities in gynecologic cytologic-histologic correlations: findings from the College of American Pathologists Gynecologic Cytopathology Quality Consensus Conference Working Group 4

The cervical epithelial cell abnormalities originate in the squamous or glandular cells and in the Pap smears range from atypia and mild-to-severe dyskaryosis to invasive cancer.11 The significance as well as consequence of these cytological diagnoses have been extensively elaborated in the 2001 Bethesda System.12 The category of Atypical Squamous Cells (ASC) includes ASC-US (ASC of undetermined significance) and ASC-H (ASC cannot exclude High Grade Squamous Intraepithelial Lesion, HSIL).

Spectrum of cervical epithelial cell abnormalities diagnosed at King Fahd Hospital of the University, Al-Khobar, Saudi Arabia

It was not clear whether such lesions were now being reported as negative or as high-grade dyskaryosis. (9) Reassuringly, a more recent study from the UK found that although the introduction of LBC decreased cytological glandular neoplasia referrals, this did not happen at the expense of missing pre-invasive and invasive cancers.

Liquid-based cervical cytology in the United Kingdom and South Africa: carcinoma of the cervix is a common disease among South African women and is globally important

"Last July I went as normal and then I received a letter in September saying I had 'severe dyskaryosis'.

One simple, five-minute test may have saved my life

In a retrospective analysis of 375 patients who had a single smear positive for mild dyskaryosis and were followed for 4 years, Mr.

Colposcopy referral may not be needed for mild dyskaryosis

This study identifies the prevalence and risk factors for cervical dyskaryosis among 200 women with and without HIV in Zimbabwe.

Cervical abnormality in women with and without HIV: prevalence and risk factors

Abnormal findings, including symptoms of mild severity in 10 women and moderate severity in 6 women, developed in 38 women in this study during a follow-up period of 11 years; severe dyskaryosis carcinoma was diagnosed in 1.

Cervical human papillomavirus screening among older women