Even
Schwann cells subsequently modulate the expression of proinflammatory cytokines, chemokines, or enzymes such as IL1[beta], TNF[alpha], and iNOS [45].
V Borlongan, "Peripheral nerve repair with cultured
schwann cells: getting closer to the clinics," The Scientific World Journal, vol.
Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat
Schwann cell precursors.
Transplantation of bone marrow stromal cell-derived
Schwann cells promotes axonal regeneration and functional recovery after complete transection of adult rat spinal cord.
Schwann cells of the olfactory nerves contain glial fibrillary acidic protein and resemble astrocytes.
(2002) proposed that the mutated GDAP1 might prevent the correct catalysing S-conjugation of reduced glutathione (antioxidant), resulting in a progressive attrition of both axons and
Schwann cells. Mutations in the small GTP-ase late endosomal protein RAB7 have also been related with axonal neuropathy.
In addition, where to obtain
Schwann cells can be a problem; the cells can be cultivated from a trace sample taken from humans, or can be cultivated from embryonic stem cells.
Scientists believe that this particular gene on chromosome 22 suppresses the growth of
Schwann cells. When this gene malfunctions,
Schwann cells can grow out of control.
It should be noted that DRG cells contained both sensory neurons and
Schwann cells in our experiment, although DRG explants had been shredded and digested.