Natamycin has been considered as a GRAS (generally recognized as safe) product by the FDA (Koontz et al., 2003; Cong et al., 2007) and also registered as a natural preservative by the European Union (EECN235) (Balaguer et al., 2014).
Natamycin, the only commercially available antifungal agent for ophthalmic use, has poor corneal penetration and precipitates on the corneal surface.
Moreover, it was found that patients who received one hourly
natamycin eye drops during day and night showed more improvement clinically than those who received one hourly
natamycin eye drops only during day time.
The use of benzoate, sorbate, and
natamycin in dairy products as additives is forbidden in Iran; only sorbate is permitted for additives in processed cheeses at a maximum level of 1000 mg/kg.
Following the shelf life study, the scientists validated the citric-acetic acid system for storage at 5 C with 20 ppm
natamycin, 1000 ppm potassium sorbate, 1000 ppm sodium benzoate, and no antimicrobials at pH 4.6 and 4.2.
Following the show, Khoury removed
Natamycin and the case has been closed by LIBNOR, but the expose had a negative impact on the dairy's sales, dropping by 60 or 70 percent.
Antibiotics,
natamycin, Vanderzant vitamin mixture, ascorbic acid and yeast were added when the mixture had cooled to 55[degrees]C, and were blended in the beaker.
But he maintained, according to international standards set by the FDA and the World Health Organization, that
natamycin was routinely used in products all over the world.
Two culture negative patients were given
natamycin and amphotericin, respectively, as fungal keratitis was suspected.