During methylene blue therapy, an alternative enzyme system, NADPH dehydrogenase, becomes the primary mechanism for MetHb reduction (31).
Other mechanisms of MetHb reduction (ascorbic acid or glutathione reduction and NADPH dehydrogenase) are considered minor pathways under physiologic conditions (27, 28), but these minor pathways are capable of reducing large amounts of MetHb when the primary reduction mechanism is compromised.
NADPH dehydrogenase affects vegetative growth, while NADPH oxidase has been reported to increase both immunity and plant cell growth (Foreman et al., 2003; Hao et al., 2006; Li et al., 2014a; Pourrut et al., 2008; Sagi et al., 2004; Wallstrom et al., 2014; Zhang et al., 2014).
The activities of hepatic mitochondrial enzymes such as isocitrate dehydrogenase (ICH) a-ketoglutarate dehydrogenase (KDH) succinate dehydrogenase (SH) malate dehydrogenase (MDH)
NADPH dehydrogenase and cytochrome C oxidase were significantly decreased in CCl4- hepatotoxic rats and administration of corosolic acid brought back these parameters towards normal.