Microscopic Polyangiitis (MPA) - Pipeline Review, H1 2019, provides comprehensive information on the therapeutics under development for
Microscopic Polyangiitis (MPA) (Cardiovascular), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.
Renal biopsy showed necrotizing crescentic glomerulonephritis, leading to the diagnosis of
microscopic polyangiitis (MPA).
KEYWORDS: ANCA associated vasculitis, Antineutrophil cytoplasmic antibodies (ANCA), Eosinophilic granulomatosis with polyangiitis, Granulomatosis with polyangiitis,
Microscopic polyangiitis.
Subsequently, rituximab was approved in 2011 for the treatment of granulomatosis with polyangiitis (in which antineutrophil cytoplasmic antibodies and myeloperoxidase are involved) and
microscopic polyangiitis (in combination with glucocorticoids).
Cevallos et al., "
Microscopic polyangiitis: clinical and laboratory findings in eighty-five patients," Arthritis & Rheumatism, vol.
Segelmark, "Incidence and survival rates in Wegener's granulomatosis,
microscopic polyangiitis, Churg-Strauss syndrome and polyarteritis nodosa," Rheumatology, vol.
Overall survival, renal survival and relapse in patients with
microscopic polyangiitis: A systematic review of current evidence.
(1-9) This review focuses on coexisting/comorbid lung and renal disease encountered in AAV, including GPA,
microscopic polyangiitis (MPA), and eosinophilic GPA (EGPA).
Severe
microscopic polyangiitis with unilateral vocal cord paralysis as initial manifestation
interjectum cutaneous infection with surgical intervention alone in a patient with
microscopic polyangiitis on chronic steroid and azathioprine therapy [17].
A p-ANCA by IIF and MPO positivity by ELISA are suggestive of
microscopic polyangiitis (MPA).
Exclusion of ANCA associated vasculitis such as
microscopic polyangiitis (MPA) and atypical presentations of giant cell arteritis (GCA) which may give rise to similar presentations is important when arriving at the correct diagnosis.