Despite its vital importance, copy number neutral
loss of heterozygosity is easily missed by standard methods.
Loss of heterozygosity on chromosome 13 and its association with delayed growth of retinoblastoma.
NF1-associated GISTs almost uniformly do not exhibit gain-of-function activation of KIT or PDGFA (pathogenesis is suggested to be from the
loss of heterozygosity of the NF1 gene) and are not likely to respond to imatinib.
The study was carried out to understand the prognostic relevance of
loss of heterozygosity (LOH) for chromosome 11 p13, 11p15 and 16q in 135 cases of Wilm's tumour.
Karyotypes and analysis of
Loss of Heterozygosity (LOH) are routine procedures to detect DNA deletion and serve as TSG location indicators.
This work details DNA microarray applications for the detection and characterization of genomic DNA-associated copy number alteration,
loss of heterozygosity, cytosine methylation, protein binding sites, regulatory elements, and replication timing, with emphasis on higher eukaryote (animal) and cancer genomics.
No
loss of heterozygosity was observed between wild and broodstock samples or between broodstock and F1 samples.
Loss of heterozygosity is a type of mutation that happens when one chromosome is lost, leaving you with only one working chromosome.
Chromosome loss with concomitant duplication and recombination both contribute most to
loss of heterozygosity in vitro.
Small, isolated populations experience genetic drift and the
loss of heterozygosity over time (14).