The patient was then found to have multiple neurofibromata, and a
Lisch nodule as well.
Lisch nodule was present in 30 out of 50 patients (60%) examined by slit lamp, 1 patients screened with cranial CT had ventricular dilatation with aqueductal stenosis and all patient had axillary or inguinal freckling.
Caption: Figure 2: (a) Microsection showing bundles of wavy spindle cells with serpentine nuclei in fascicles (H&E, x10x), (b) Strong S-100 positivity of tumor cells (x40x), (c) cafe au lait macule (arrow) in the back, (d) axillary freckle, (e)
Lisch nodule (arrow) in slit lamp examination, and (f) father of patient with multiple cutaneous neurofibromas.
Consultation with ophthalmologist found no
Lisch nodule (iris hamartoma).
Ophthalmologic examination revealed
Lisch nodule present in both eyes.
Melanocytic hamartomas of the iris (
Lisch nodules), axillary freckling (Crowe's sign), or multiple cutaneous neurofibromas serve as additional clues to neurofibromatosis.
Her ophthalmological examination revealed the presence of
Lisch nodules on her iris.
Most individuals with NF1 will present with pigmentary lesions (CALMs, freckles or
Lisch nodules) and neurofibromas.
Supportive tests include an ophthalmologic exam to detect
Lisch nodules and cataracts.
The differential diagnosis of iris mammillations is from
Lisch nodules, iris nevi, iris melanoma, Brushfield flecks, retinoblastoma, and the Cogan-Reese (ICE) syndrome [1-7].
Second, patients of neurofibromatosis often have typical skin manifestations of cafe au lait spots or
Lisch nodules. Third, the lack of neural foramina erosion or widening on MRI helped us rule out the diagnosis of neurofibromatosis.
Clinically, NF-1 is characterized by cafe-au-lait spots, freckling, skin neurofibroma, plexiform neurofibroma, bony defects,
Lisch nodules, and tumors of the central nervous system.