IL26

A gene on chromosome 12q15 that encodes a protein belonging to the IL10 family of cytokines thought to have a pro-inflammatory role in mucosal immunity; it is inhibited by heparin. IL26:
• Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT;
• Induces expression of SOCS3, TNF-alpha and IL-8;
• Induces secretion of IL-8 and IL-10 and surface expression of ICAM1; and
• Decreases proliferation of intestinal epithelial cells.

Molecular pathology
IL26 may play a role in inflammatory bowel disease.

References in periodicals archive

To assess the severity of aGvHD, special markers may be considered, such as fecal alpha-1 antitrypsin, fecal calprotectin, TIM3, sTNFR1, ST2, IL26, and Reg3alpaa (19).

Current approach to early gastrointestinal and liver complications of hematopoietic stem cell transplantation

The former is specific for the IFNL receptor (IFNLR), while the latter is shared with the type II cytokine receptors for IL-10, IL-22, and IL26 [45].

The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy

In addition, the expression of 7 cytokines genes (IL-22, VEGFA, IL26, CXCL14, BMPER, IL-17D, and CCL20) and 16 receptor genes (IL-22RA1, CXCR3, IL-17RC, IL-1RAPL2, IFITM5, NRG2, TNFRSF14, LEPREL2, IL-11RA, LTBP2, ILDR1, IL-17RD, MC1R, IL-22RA2, LEPREL1, and LILRA5) were significantly downregulated by 3.6- to 5.7-fold and 2.14- to 9.12-fold, respectively with p < 0.01 and fold [greater than or equal to] 2 (Figures 4 and 5).

RNA-seq profiles of immune related genes in the spleen of necrotic enteritis-afflicted chicken lines

Nearby genes implicated as possibly playing a role in ulcerative colitis include the ring finger protein 186 (RNF186), OTU domain containing 3 (OTUD3), and phospholipase A2, group IIE (PLA2G2E) - genes on chromosome 1p36, and the interferon, gamma (IFNG), interleukin 26 (IL26), and interleukin 22 (IL22) genes on chromosome 12q15 that play an important role in inflammation.

Genetic markers associated with ulcerative colitis risk identified

Human T17 cells express retinoic acid receptor-related orphan receptor (ROR)C and produce, besides IL-17A, also IL-17F, IL-21, IL-22, and IL26 [7, 8].

IL-17A in human respiratory diseases: innate or adaptive immunity? Clinical implications

According to them, nearby genes implicated as possibly playing a role in ulcerative colitis include the ring finger protein 186 (RNF186), OTU domain containing 3 (OTUD3), and phospholipase A2, group IIE (PLA2G2E) - genes on chromosome 1p36, and the interferon, gamma (IFNG), interleukin 26 (IL26), and interleukin 22 (IL22) genes on chromosome 12q15.

Scientists identify new genetic markers for ulcerative colitis