HSP90

A generic term for a family of molecular chaperones which play a key role in protein folding and quality control for a range of client proteins. Functional HSP90s operate as dimers, have intrinsic ATPase activity, act in concert with other chaperones (e.g., HSP70) and are regulated by co-chaperones/accessory proteins (e.g., HOP, CDC37). HSP90s interact with more than 100 proteins, including kinases (e.g., Raf-1), nuclear hormone receptors (e.g., oestrogen receptor), transcription factors (e.g., P53), GPCRs (e.g., CB2 receptors) and ion channels (e.g. CFTR). In humans, the HSP90-beta isoform is constitutively expressed (i.e., at baseline), whereas HSP90-alpha isoforms are induced by stress. HSP90 plays an important role in some tumour cell types by stabilising mutated oncogenic proteins.

Mentioned in

References in periodicals archive

(2014) indicated that in Hsp90 of the sea cucumber A.

Hsp70 function and polymorphism, its implications for mollusk aquaculture: a review

This finding disfavors that a dependency of WT1 stability on HSP90 (Bansal et al., 2010) is linked to HDAC6.

Human Platelet Lysate as Validated Replacement for Animal Serum to Assess Chemosensitivity

A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease.

Disease Models and Imaging Techniques Used in Pre-Clinical Studies--Endocrine Models/Klinik Oncesi Calismalarda Kullanilan Hastalik Modelleri ve Goruntuleme Teknikleri-Endokrinolojik Modeller

Fragment screening by weak affinity chromatography: comparison with established techniques for screening against HSP90. Anal Chem 2013; 85:6756-66.

Analysis of Biological Interactions by Affinity Chromatography: Clinical and Pharmaceutical Applications

Not surprisingly, in many animals nitric oxide synthase (NOS) requires an interaction with heat-shock protein 90 (HSP90) to keep the essential heme cofactor bound (Bishop and Brandhorst, 2003).

Transcriptomic Basis of Metamorphic Competence in the Salt-Marsh-Dwelling Polychaete Capitella teleta

The downstream components; mitogen-activated protein kinases, Hsp90 and calmodulins are involved in the activation of Heat-shock transcription factors (Hsf).

PLANTS SENSORY-RESPONSE MECHANISMS FOR SALINITY AND HEAT STRESS

Report is also available in abating HSP expression (HSP70 and HSP90) due to transportation stress lowering muscle pH and higher drip loss [5].

Changes in expression of monocarboxylate transporters, heat shock proteins and meat quality of Large White Yorkshire and Ghungroo pigs during hot summer period

The HSP90 protein family comprises HSP90a (HSPC1), HSP90b (HSPC3), and gp96 (HSP4).

Inflammatory and Anti-Inflammatory Equilibrium, Proliferative and Antiproliferative Balance: The Role of Cytokines in Multiple Myeloma

In the "plant-pathogen interaction pathway," three unigenes encoding the molecular chaperone heat shock protein (HSP90) functioning in the hypersensitive response (HR), K09487 (c100585.graph_c0; c155839.graph_c0), and K04079 (c124009.graph_c0) were identified (Figure 8).

Comparative Transcriptome Analyses of Resistant and Susceptible Near-Isogenic Wheat Lines following Inoculation with Blumeria graminis f. sp. tritici