Overexpression of HSP-70 inhibits the phosphorylation of
HSF1 by activating protein phosphatase and inhibiting protein kinase C activity.
The
HSF1 "plays a crucial role in the response of brain cells to prenatal environmental insults," the researchers reported.
Both Hsps regulate the activation of the
HSF1 transcription factor, which is linked to the transcriptional stress response [33, 34].
Induction of heat shock proteins by hyperthermia and noise overstimulation in
hsf1 -/- mice.
The member of the Hsf family,
Hsf1 is involved in the Hsps induction owed to heat shock and other kinds of stress (8-10).
The gene, called heat-shock factor 1 (
Hsf1), doesn't itself trigger cancer.
In addition, decreases in ATP levels have been previously found to elicit the induction of HSPs by DNA binding and activation of the transcriptional factor
HSF1 (39).