Glycolipid (cerebroside and ganglioside), particularly cerebroside, has been proved to exhibit various physiological activities, including antitumor/cytotoxic (Natori et al., 1994; Jin et al., 1994; Li et al., 1995; Chen et al., 2009), antifungal (Jin et al., 1994), immunomodulatory, cyclooxygenase inhibitory, and antifouling activities (Mansoor et al., 2007).
Since alteration in cell property is also linked to biofilm formation and adherence and as a known fact of matter outer portion of nontuberculous mycobacteria (NTM) are attached to the
glycolipids [30, 31], hence change in the composition of
glycolipids could change the formation of biofilm or adherence of mycobacterium.
[5] Since sialic acids are major constituents of glycoproteins and
glycolipids, this study is concerned with TSA and/or LBSA levels.
In this regard, we have identified
glycolipid accumulation and, specifically, lyso-Gb3 accumulation as a driver of uPAR expression in podocytes (Figure 2).
These cells recognize lipids and
glycolipids presented by CD1d molecules [82].
This "sugar" coating consists of several carbohydrate moieties of structural membrane
glycolipids and glycoproteins which serve as a backbone for support and cell-cell communication.
Mycobacterial
glycolipids like lipoarabinomannan (LAM), lipomannans (LM), phosphatidylinositol mannosides (PIM2, PIM6), and a 19-kDa lipoprotein, are the mycobacterial PAMPs believed to cause M[PHI] activation via the TLR2 activating innate pathway by regulating tumour necrosis factor (TNF-[alpha]) and IL-10 secretion reported for human monocyte-derived M[PHI]s.
In the following sections, the response and role of the PM lipid species (i.e., phospholipids,
glycolipids, sterols, fatty acids) in adaptation to salt imposition are discussed.