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GLUD1

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GLUD1

A gene on chromosome 10q23.3 that encodes glutamate dehydrogenase 1, a mitochondrial matrix enzyme which catalyses the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. It plays a key role in regulating amino acid-induced insulin secretion. GLUD1 is allosterically activated by ADP and inhibited by GTP and ATP; it may be involved in learning and memory by increasing the turnover of the neurotransmitter glutamate.

Molecular pathology
Missense mutations of GLUD1 cause hyperinsulinemic hypoglycaemia type 6.
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References in periodicals archive
Hu, "A novel mutation in the glutamate dehydrogenase (GLUD1) of a patient with congenital hyperinsulinism-hyperammonemia (HI/HA)," Journal of Pediatric Endocrinology & Metabolism, vol.
Clinical and Molecular Spectrum of Glutamate Dehydrogenase Gene Defects in 26 Chinese Congenital Hyperinsulinemia Patients
Abbreviations AAT: Aspartate aminotransferase ACSF: Artificial cerebrospinal fluid AD: Alzheimer's disease GAD: Glutamate decarboxylase GDH: Glutamate dehydrogenase GS: Glutamine synthetase M: Molecular ion OCR: Oxygen consumption rate PAG: Phosphate-activated glutaminase T2DM: Type 2 diabetes mellitus.
Impaired Hippocampal Glutamate and Glutamine Metabolism in the db/db Mouse Model of Type 2 Diabetes Mellitus
Myoclonic absence epilepsy with photosensitivity and a gain of function mutation in glutamate dehydrogenase. Seizure 2008;17:658-664.
Early Presentation of Hyperinsulinism/Hyperammonemia Syndrome in Three Serbian Patients
In addition, low temperature can reduce plant nitrogen (N) uptake capacity and the activity of enzyme in N metabolism, such as glutamate dehydrogenase (GDH) (Lu et al., 2005; Lloyd et al., 2011).
Calcium Alleviates Temperature Stress by Regulating Nitrogen and Respiratory Metabolism in Malus baccata Roots
Glutamate dehydrogenase (GDH) was assayed by the method of Pahlich and Joy [51].
Agronomic effectiveness of mycorrhizal Cicer arietinum L. plants on mechanism of proline in imparting protection, against NaCl stress
Glutamate dehydrogenase (GDH) a mitochondrial enzyme catalyses the oxidative deamination of glutamate providing a- ketoglutarate to the Krebs cycle (Reddy and Venugopal 1990).
Effect of a Synthetic Pyrethyroid Cypermethrin on Aminotransferases and Glutamate Dehydrogenase Activities in Gill Liver and Muscles of a Freshwater Fish Cyprinus carpio
Glutamate dehydrogenase and [Na.sup.+]-[K.sup.+] ATPase expression and growth response of Litopenaeus vannamei to different salinities and dietary protein levels.
Growth, body composition, and ammonia tolerance of juvenile white shrimp Litopenaeus vannamei fed diets containing different carbohydrate levels at low salinity
Glutamate Dehydrogenase. In addition to GS and GOGAT, another enzyme potentially involved in ammonia metabolism is GDH.
Effect of chromium(VI) toxicity on enzymes of nitrogen metabolism in clusterbean (Cyamopsis tetragonoloba L.)
The proposed mechanism is that leucine enters the beta cells and allosterically activates mitochondrial glutamate dehydrogenase (GDH).
Interaction of ingested leucine with glycine on insulin and glucose concentrations
The guidelines list as an acceptable alternative a two-step method using a glutamate dehydrogenase test as a screen; if positive, it is to be followed by PCR or enzyme immunoassay.
No C. difficile testing in infants with persistent diarrhea
A proteomic study of the culture filtrate demonstrated that the most abundant proteins are S-layer protein, TcdA, TcdB, and NAD-specific glutamate dehydrogenase. Taken together, data presented in this study provide performance characteristics and the basis for future development of improved MS-based detection and quantification methods in determining the factors involved in C.
Proteomic analysis and label-free quantification of the large Clostridium difficile toxins
(iii) related enzymes may exhibit SI in some conditions, as is the case glutamate dehydrogenase [4].
What happens when the wrong equation is fitted to data?
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