SIRT4

A gene on chromosome 12q24.31 that encodes an NAD-dependent protein ADP-ribosyl transferase that catalyses the transfer of ADP-ribosyl groups onto target proteins (e.g., mitochondrial GLUD1), inhibiting its enzyme activity. SIRT4 interacts with GLUD1, IDE and SLC25A5, is widely expressed, especially in vascular smooth muscle, striated muscle and in beta-cells in pancreas islets; it downregulates insulin secretion.

References in periodicals archive

SIRT4, unlike other sirtuins, mostly functions as a histone ADP-ribosyltransferase but does not have NAD-dependent deacetylase activity [52].

Emerging Evidence concerning the Role of Sirtuins in Sepsis

As discussed above, other Sirtuins, especially, SIRT4 is also a mitochondrial deacetylase as SIRT3 and functions as tumor suppressor via modulating glutamine metabolism.

Sirtuins Function as the Modulators in Aging-related Diseases in Common or Respectively

SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis.

Mitochondria: overlooking these small organelles can have huge clinical consequences in treating virtually every disease

SIRT4, a less studied mitochondrial sirtuin, is an integral part of the metabolic response to genotoxic stress.

Marcia Haigis to Keynote Present at 5th Cancer Targets & Therapeutics - July 7-8, 2014, in Boston

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