PLCG1

A gene on chromosome 20q12-q13.1 that encodes a phospholipase which mediates production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and plays an important role in regulating signalling cascades. PLCG1 is activated by ligand-mediated activation of receptor-type tyrosine kinases (e.g., PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4) and plays a role in actin reorganisation and cell migration.

Mentioned in

NTRK3

References in periodicals archive

We found for the PLCG cascade (BDNF, PLCG1, and PLCG2) that [PM.sub.2.5] exposure during the first month (p = 0.001) and the first trimester (p = 0.009) of pregnancy was associated with significantly lower levels of placental gene expression at birth (Table 3).

The binding of BDNF to its receptor TRKB initiates three main signaling cascades: pLc gamma cascade (PLCG1 and PLCG2), AKT cascade (AKT1, AKT2, and AKT3) and SOS cascade (SOS1, SOS2, and SYN1).

AKT cascade Time windows BDNF, AKT1, AKT2, AKT3 [beta] (95% CI) p-Value First month of pregnancy -0.03 (-0.07, 0.0009) 0.06 Trimester 1 -0.03 (-0.08, 0.02) 0.2 Trimester 2 0.02 (-0.03, 0.07) 0.4 Trimester 3 -0.03 (-0.09, 0.02) 0.2 SOS cascade Time windows BDNF, SOS1, SOS2, SYN1 [beta] (95% CI) p-Value First month of pregnancy -0.1 (-0.2, -0.07) 0.00002 Trimester 1 -0.15 (-0.2, -0.08) 0.0001 Trimester 2 -0.05 (-0.2, 0.04) 0.3 Trimester 3 -0.09 (-0.2, 0.02) 0.1 PLCG cascade Time windows BDNF, PLCG1, PLCG2 [beta] (95% CI) p-Value First month of pregnancy -0.08 (-0,1.

In utero fine particle air pollution and placental expression of genes in the brain-derived neurotrophic factor signaling pathway: an environage birth cohort study

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