We investigated the phenotypes associated with the
ergosterol biosynthesis pathway in IFM 63240, a representative of the isolate from the third testing day.
Actua inhibiendo la lanosterol 14-[alfa] demetilasa, enzima necesaria para la sintesis de
ergosterol, por lo que altera la membrana fungica y el crecimiento celular (38).
Morita, "Molecular mechanisms of antifungal agents associated with membrane
ergosterol. Dysfunction of membrane
ergosterol and inhibition of
ergosterol biosynthesis," in In Vitro and in Vivo Evaluation of Antifungal Agents, K.
Despite differences in degradative ability, both fungi produced similar amounts of
ergosterol, a proxy for total fugal biomass [22], as well as similar amounts of secreted protein on sorghum when compared at equivalent timepoints.
While amphotericin B has a higher affinity for the
ergosterol component of the fungal cell membrane, it can also bind to the cholesterol component of the mammalian cell leading to cytotoxicity19.
The antifungal drugs currently available for the treatment of invasive mycoses can be divided into four different classes on the basis of their mechanisms of action: (1) Alteration of membrane function (amphotericin B); (2) inhibition of DNA or RNA synthesis (flucytosine); (3) inhibition of
ergosterol biosynthesis (azoles [fluconazole, itraconazole, and the newer agents voriconazole, posaconazole, and ravuconazole]); and (4) inhibition of glucan synthesis (echinocandins [caspofungin, micafungin, and anidulafungin]).
Ravuconazole demonstrates antifungal activity by inhibiting
ergosterol biosynthesis, a membrane component of fungal cells.
Xuezhikang contains the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor lovastatin, flavonoids,
ergosterol amino acids, unsaturated fatty acids, trace elements, and other effective components.
albicans is performed using systemic and topical antifungal, mainly from the group of azole drugs, the main representatives are ketoconazole, miconazole, itraconazole, fluconazole, voriconazole and posaconazole, which have the same mechanism of action, inhibiting the synthesis of
ergosterol. The foremost differences of this group of drugs are pharmacokinetic and toxicity (Guinea et al., 2014).
In the absence of oxygen that stimulates
ergosterol production by yeast, unsaturated fatty acids and sterols derived from grapes are essential to anaerobic yeast growth (2-4 mg/L phytosterols is required for maximal growth).