This includes the discovery of new therapeutic targets that exploit vulnerabilities of cancer cells, such as their dependence on oncometabolites (e.g., inhibition of mutant isocitrate
dehydrogenases that produce D-2-hydroxyglutarate) (75, 76), as well as downstream targets of the oncometabolites (e.g., metabolic and epigenetic modulators) (7, 77).
Characterization of two mitochondrial flavin adenine dinucleotide-dependent glycerol-3-phosphate
dehydrogenases in Trypanosoma brucei.
Developmental changes of mammalian lactic
dehydrogenases. Biochemistry, 2: 116-121.
Hedderich, "Two malate
dehydrogenases in Methanobacterium thermoautotrophicum," Archives of Microbiology, vol.
Background: Aldehyde
dehydrogenase 2 (ALDH2) is involved in the pathophysiological processes of cardiovascular diseases.
The glutathione pathway is paramount to antioxidant defense and glucose-6-phosphate
dehydrogenase (G6PD)-deficient cells do not cope well with oxidative damage.
Additionally,
dehydrogenase enzyme activity is commonly used as an indicator of biological activity in soils [11].
Two of these activities are due to pyridine nucleotide-disulfide family of enzymes, namely, two paralogous dihydrolipoamide
dehydrogenases and NAD(P)H-nitrite reductase.
Lupianez, "Kinetic properties of hexose-monophosphate
dehydrogenases. I.
(ii) related enzymes exhibit SI in the conditions employed, as is the case for IMP
dehydrogenase [2], and