Demographic and clinical characteristics of study population and the chemotherapeutic agents n Chemotherapeutic agents Patients 28 Sex (M/F) 6/22 Age (years), 52.3[+ or -]9.6 mean[+ or -]SD Cancer related 22 Breast cancer 9 Vinorelbine, docetaxel,
clodronate, ietrozole, trastuzumab, capecitabine paclitaxel, dexamethasone sodium phosphate, gemcitabine, cisplatin Colorectal cancer 7 5-FU, leucovorin oxaliplatin, cisplatin, docetaxel, bevacizumab, irinotecan Gastric cancer 2 5-FU, leucovorin, cisplatin, docetaxel Other malignancies Methotrexate, cytarabine, ifosfamide, mesna, etoposide Noncancer related 6 M, male; F, female; FU, fluorouracil.
Bisphosphonates are mainly of two sub classes, non Nitrogen containing like Etidronate,
Clodronate, Tiludronate and Nitrogen containing bisphosphonates Pamidronate, Nerid-ronate, Olpadronate, Alendronate, Ibandronate, Risedronate.
All bisphosphonates showed a significantly increased percentage change in BMD at the lumbar spine compared to calcium except
clodronate. Pamidronate with calcium and Vitamin D analogs showed improved BMD in comparison to
clodronate with calcium (mean difference [MD], 9.84; 95% credibility interval [CrI], 1.06-19.70).
Since murine monocytes and other indigenous phagocytic cells are responsible for poor engraftment, several targeted techniques aimed at their eradication were developed such as the use of anti-murine SIRP[alpha], CD47, or Ncf1 knockout, and
clodronate liposomes [42-44].