CASP1

A gene on chromosome 11q23 that encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution-phase of cell apoptosis, as well as various stages of embryological development.

Molecular pathology
CASP1 mutations may play a role in Huntington’s disease.

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References in periodicals archive

In addition, CD11b+ cells expressed approximately 40-fold more Casp1 and approximately 20-fold more Tlr4 than CD11b- cells (all p-values < 0.001; see Supplemental Material, Figure S2G and F, respectively).

Maternal stress and effects of prenatal air pollution on offspring mental health outcomes in mice

RESULTS: Androgen-dependent and - independent human prostate cancer cell lines (LNCaP and PC3, respectively), androgen-dependent and -independent murine prostate cancer cell lines (CASP2.1 and CASP1.1, respectively), as well as noncancerous human benign prostate hyperplasia BPH-1 cell line, were used in the study.

Citrus pectin

2000), Capn2 (Squier and Cohen 1997), Casp1 (Zhou et al.

Gene expression alterations in immune system pathways in the thymus after exposure to immunosuppressive chemicals

Stimulation of the P2X7R also elicits the production of IL-1[beta] and its maturation via CatS and CASP1 [36], which can further increase microglia activation via the interleukin receptor IL1R [37] and it is also a key contributor in the hyperexcitability of the nociceptive dorsal horn neurons [14].

Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain

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