CARD16

A gene on chromosome 11q22.3 that encodes a protein which downregulates procaspase-1/CASP1 activation by inhibiting the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release in response to lipopolysaccharides during inflammation. CARD 16 induces NF-kappa-B activation during the pro-inflammatory cytokine response; it inhibits CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death (but not ER stress-mediated cell death). It blocks CASP1 and CASP4 activation, possibly by preventing the interaction between CASP1 and RIPK2.

Molecular pathology
CARD16 is downregulated in patients with clinical Huntington’s disease.

References in periodicals archive

The "peptidase inhibitor activity" annotation contains 10 genes, including APP, CARD16, SERPINB2, BIRC6, SERPINB1, SLPI, SERPINB3, HSPA5, SERPINB13, and OVOS2.

Exploration of potential roles of a new LOXL2 splicing variant using network knowledge in esophageal squamous cell carcinoma

DEPARTMENTS Best of ...3 Music4 Wild Card16 Screen17 Calendar22 LISTINGS Now Showing20 Stage25 Art Exhibits25 Museums25 Karaoke26 Concerts26 On the cover Don't expect a lot of shoe-gazing tonight when Juliette Lewis & the Licks writhe around John Henry's Photo by Nabil Elderkin Ticket staff Ticket Editor Mark Johnson (Ext.

FRESH SHEET

DEPARTMENTS Best of ...3 Music4 Wild Card16 Dining Out19 Screen20 Calendar27 LISTINGS Now Showing25 Stage30 Art Exhibits30 Museums30 Karaoke30 DJ Dances31 Concerts31 On the cover David Amaral lives the good life as one of `The Producers' Photo by Paul Kolnik

FRESH SHEET

All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.