If catheters were found disconnected or otherwise suspected to have been compromised (as indicated by, e.g., lack of responding during cocaine maintenance sessions, observed swelling, unusual difficulty or ease of injection during presession flush), patency was tested using an acute dose of methohexital (0.5 mg/kg;
Brevital, Portage Pharmacy, Portage, Michigan) delivered via bolus injection through the catheter, and the animal was subsequently observed for prototypic signs of acute administration of a rapid-onset, short-acting barbiturate (i.e., loss of righting reflex and lack of muscle tone).
Methohexital (
brevital) (0.75 to 1.0 mg/kg IV bolus) is the most preferred anesthetic because of its shorter duration of action and lower association with postictal arrhythmias than thiopental (pentothal) (usual dose 2-3 mg/kg IV).
The injectable agents include droperidol (Inapsinc), etomidare (Amidate), fospropofol (Lusedra), ketamine (Ketalar), methohexital (
Brevital), midazolam (Versed), propofol (Diprivan), and sodium thiopental (Pentothal).
Brevital (Ranbaxy Pharmaceuticals, Inc.) was used unilbrmly for provocative testing.
General anesthesia was induced during each treatment with sodium
brevital 60 mg and muscle paralysis produced by succinylcholine 60 mg.
Rats were anesthetized with an intraperitoneal (ip) injection of 30-40 mg/kg body weight sodium methohexital (
Brevital; Eli Lilly and Co., Indianapolis, IN) and were intratracheally instilled using a 20-ga, 4-inch ball-tipped animal feeding needle.
Other sedatives have also been used in memory recovery interviews - barbiturates (for example,
Brevital, Nembutal, and Pentothal) and benzodiazepines (for example, Ativan and Valium).
Rats were anesthetized with an intraperitoneal injection of sodium methohexital (30-40 mg/kg body weight
Brevital; Eli Lilly, Indianapolis, IN) and were intratracheally instilled using a 20-gauge 4-in.
Rats were anesthetized with an intraperitoneal injection of 30-40 mg/kg body weight sodium methohexital (
Brevital; Eli Lilly and Company, Indianapolis, IN) and were intratracheally instilled using a 20-gauge 4-inch ball-tipped animal feeding needle.
Male Sprague-Dawley rats (7-8 weeks of age) were lightly anesthetized by an intraperitoneal (ip) injection of sodium methohexitol (
Brevital) and instilled with ROFA (0.1, 0.25, 1, or 2 mg/rat, IT, in a 300 pL sterile saline suspension) according to the method of Brain et al.
On the afternoon before microdialysis, animals were anesthetized intraperitoneally using 35-50 mg/kg of
Brevital (methohexital sodium; Jones Pharma, Inc., St.