second letter of the Greek alphabet, β; used to denote the second position in a classification system. Often used in names of chemical compounds to distinguish one of two or more isomers or to indicate the position of substituent atoms or groups in certain compounds. Also used to distinguish types of radioactive decay; brain rhythms or waves; adrenergic receptors; secretory cells of the various organs of the body that stain with basic dyes, such as the beta cells of the pancreas; and the type of hemolytic streptococci that produce a zone of decolorization when grown on blood media.
beta-adrenergic blocking agent (
beta-blocker) any of a group of drugs that block the action of
epinephrine at
beta-adrenergic receptors on cells of effector organs. There are two types of these receptors: β
1-receptors in the myocardium and β
2-receptors in the bronchial and vascular smooth muscles. The principal effects of beta-adrenergic stimulation are increased heart rate and contractility, vasodilation of the arterioles that supply the skeletal muscles, and relaxation of bronchial muscles.
Because of their effects on the heart, these agents are used to treat
angina pectoris,
hypertension, and cardiac
arrhythmias. And, because they decrease the workload of the heart, they are effective in reducing the long-term risk of mortality and reinfarction after recovery from the acute phase of a
myocardial infarction. They are an important adjunct in treatment of
heart failure and are also used for prophylaxis of
migraine.
Nonselective beta-adrenergic blocking agents affect both types of receptors and can produce bronchospasm in patients with asthma or chronic obstructive pulmonary disease. If such patients need one of these drugs, they should be given a cardioselective one that preferentially blocks the β
1-receptors in the heart.
Nonselective agents include
propranolol (
Inderal), used for treatment of angina, hypertension, arrhythmias, and migraine and for prophylaxis after the acute phase of a myocardial infarction;
nadolol (
Corgard), used for treatment of angina and hypertension; and
timolol, used as an ophthalmic preparation (
Timoptic) for treatment of glaucoma and as an oral preparation (
Blocadren) for treatment of hypertension and for prophylaxis after the acute phase of a myocardial infarction. Cardioselective beta-adrenergic blocking agents are used for treatment of hypertension and include
atenolol (
Tenormin) and
metoprolol (
Lopressor).