(27) Acute rheumatic heart disease can result in the formation of granulomatous lesions known as Aschoff bodies, which tend to be perivascular in location and may contain enlarged macrophages with nuclear chromatin condensed into a wavy ribbon resembling a caterpillar, that is,
Anitschkow cells. (4,27) Utilization of the recently revised Jones criteria can aid in the diagnosis of this entity.
Larger mononuclear cells called
Anitschkow cells may be seen within the nodule and, on cut section, bear an owl-eye appearance.
It is manifested by Aschoff bodies, which are discrete, commonly perivascular, areas of fibrinoid degeneration surrounded by lymphocytes, occasional plasma cells, and plump macrophages with their nuclear chromatin clumped in a wavy ribbon resembling a caterpillar (
Anitschkow cells).