accumulation

A build-up, assembly; the process of accumulating, collecting together.

Medspeak
The progressive increase in the concentration of a chemical, drug, or other agent in an organism or tissue, due to higher doses than can be metabolised, or due to poor metabolism of the agent; the amount of a drug or therapeutic agent in the body, which after the drug has reached a state of equilibrium, is a function of the dose interval and the drug’s T1⁄2.

Equilibrium usually requires a time interval of 4- to 6-times the drug’s half-life, and depends on the rates of absorption and elimination; the drug continues to accumulate until the amount of drug administered in a time period equals that eliminated in the same period.

Factors in accumulation
Selective binding of the drug in tissues, concentration of fat soluble drugs in fat, absent or slow metabolism of the drug, slow excretion of the drug, and intercurrent illness; accumulation continues until the amount eliminated per dosage interval is equal to the amount administered during that time.

accumulation

A build-up, assembly; the process of accumulating, collecting together Therapeutics The amount of drug in the body relative to the amount lost by elimination, which is a function of ratio of the dose interval and the drug's half-life; accumulation continues until the amount eliminated per dosage interval is equal to the amount administered during that time. Cf Absorption.

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References in periodicals archive

WASA's spokesperson Imtiaz Ghori said, 'It was normal rain of 16 millimetres and WASA staff kept all the locations clear of water accumulation. Localities, where there was more water accumulation, are being cleared by WASA using machinery.'

WASA's claims go down the drain

The relationship between hail accumulation and time-averaged maximum VII leads to clustering into three main groups: i) storms with low VII of <50 kg [m.sup.-2] produced <3 cm of accumulated hail and had low accumulation rates of <0.4 cm [min.sup.-1]; ii) storms with moderate VII between 50 and 150 kg [m.sup.-2] produced moderate-to-deep hail accumulations and had moderate-to-fast (0.4-0.9 cm [min.sup.-1]) time-averaged accumulation rates, depending on the storm speed; and iii) storms with large VII of >150 kg [m.sup.-2] produced deep hail (>10 cm) and accumulation rates of 0.9-2.5 cm [min.sup.-1].

CHAT: The Colorado Hail Accumulation from Thunderstorms Project: The CHAT project aims to collect hail accumulation reports and study the behavior of hail-producing thunderstorms with dual-polarization weather radars and a lightning mapping array

The amount of N, P, K, Ca and Mg accumulated during the jambu growth cycle showed similar trends to dry matter accumulation, ie, 18 DAT.

Growth and accumulation of nutrients in organic jambu

'The steepest slowdowns in capital accumulation are expected in China, where policy efforts to rein in credit growth continue, and the Philippines, where a surge in public investment is expected to fade,' it said.

PH growth to remain fastest in Asean

The Cambridge Centre for Risk Studies indicates that cyber accumulation scenarios should include the following:

WATCH THE CONCENTRATIONS With a fast-growing cyber insurance marketplace and the rising threat of global cyber shocks, insurers must have a robust cyber accumulations framework

The accumulation of nutrients was determined through the multiplication of the concentration of the nutrient by the dry mass corresponding to each plant part.

Accumulation of macronutrients in different parts of sunflower fertilized with cassava wastewater/Acumulo de macronutrientes em distintas partes de girassol adubado com manipueira

Key words: Vetiver; Imperata; Pennisetum; Spiked heavy metal; Heavy metal accumulation.

PHYTO-ASSESSMENT OF SOIL HEAVY METAL ACCUMULATION IN TROPICAL GRASSES

Industrial and agricultural activities have been reported to be the leading potential source of the accumulation of pollutants in the aquatic environment including the sea (Tarra-Wahlberg et al., 2001; Akif et al., 2002).

Heavy Metal Concentration in Sardinella longiceps (Valeciennes, 1847) from Balochistan Coast

The ZoneFlex Advanced maximizes carton control and boosts throughput in zero-pressure accumulation conveyor applications.

Accumulation conveyor maximizes carton control, throughput

Mir1-CP accumulation is regulated by the jasmonic-acid (JA) pathway.

MIR1-CP protein responses to herbivore feeding and jasmonic-acid pathway disruption