Autoantibodies to GP2, the major zymogen
granule membrane glycoprotein, are new markers in Crohn's disease.
Tumor cells exhibited clear cytoplasm, were focally vacuolated, and lacked zymogen
Supplementation of factor XIII-deficient plasma with the purified zymogen
," Journal of Clinical Investigation, vol.
Wang, "Phenoloxidase and its zymogen
are required for the larvalpupal transition in Bactrocera dorsalis (Diptera: Tephritidae)," Journal of Insect Physiology, vol.
Another protective mechanism to prevent the premature activation of trypsinogen to trypsin inside the pancreatic duct is rapidly sweeping out zymogens
from the pancreas.
These enzymes are generally secreted into the duodenum in an inactive form (zymogen
As a key enzyme in the melanization cascade, PO is usually synthesized and released into the hemolymph as the inactive zymogen
In vertebrates and chelicerates, the initiation of the polymerization of the precursor structural protein into the fibrils of the clot involves the proteolytic activation of a soluble zymogen
. The protolyzed zymogens
, fibrin in vertebrates (Weisel, 2005) and coagulin in chelicerates (Kawasaki et al., 2000), assemble into the clot fibrils.
The noncatalytic pro-PSA zymogen
can be converted in vitro to catalytically active PSA by catalytic hK2 (6), which suggests that hK2 may be a physiological activator of PSA (7).
Activation of pro-MMP-2 consists of various overlapping processes, involving a complex formation that consists of the zymogen
MMP-2, MT1-MMP, and TIMP-2.
This leads to production of the zymogen
interleukin 1 beta (IL-1[beta]), which is proteolytically processed by caspase-1, rendering it biologically active.
In addition, we analyzed other structural aspects including the position of conserved residues and the cleavage site of the zymogen
and presented a preliminary phylogenetic analysis of selected members of this subfamily.