zymogen


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Related to zymogen: zymogen granules

zymogen

 [zi´mo-jen]
an inactive precursor that is converted into an active enzyme by action of an acid or another enzyme or by other means; a proenzyme. adj., adj zymogen´ic.

pro·en·zyme

(prō-en'zīm),
The precursor of an enzyme, requiring some change (usually the hydrolysis of an inhibiting fragment that masks an active grouping) to render it active; for example, pepsinogen, trypsinogen, profibrolysin.
Synonym(s): zymogen

zymogen

(zī′mə-jən)
n.

pro·en·zyme

(prō-en'zīm)
The precursor of an enzyme, requiring some change (usually the hydrolysis of an inhibiting fragment that masks an active grouping) to render it active, e.g., pepsinogen, trypsinogen, profibrinolysin.
Synonym(s): zymogen.

zymogen

The inactive protein precursor of an ENZYME.

zymogen

an inactive precursor of an enzyme, particularly those concerned with protein digestion, for example, PEPSINOGEN and TRYPSINOGEN. Zymogens require ACTIVATION ENERGY to become functional.
References in periodicals archive ?
Autoantibodies to GP2, the major zymogen granule membrane glycoprotein, are new markers in Crohn's disease.
Supplementation of factor XIII-deficient plasma with the purified zymogen," Journal of Clinical Investigation, vol.
Wang, "Phenoloxidase and its zymogen are required for the larvalpupal transition in Bactrocera dorsalis (Diptera: Tephritidae)," Journal of Insect Physiology, vol.
Another protective mechanism to prevent the premature activation of trypsinogen to trypsin inside the pancreatic duct is rapidly sweeping out zymogens from the pancreas.
These enzymes are generally secreted into the duodenum in an inactive form (zymogen or proenzyme).
As a key enzyme in the melanization cascade, PO is usually synthesized and released into the hemolymph as the inactive zymogen prophenoloxidase (proPO).
In vertebrates and chelicerates, the initiation of the polymerization of the precursor structural protein into the fibrils of the clot involves the proteolytic activation of a soluble zymogen. The protolyzed zymogens, fibrin in vertebrates (Weisel, 2005) and coagulin in chelicerates (Kawasaki et al., 2000), assemble into the clot fibrils.
The noncatalytic pro-PSA zymogen can be converted in vitro to catalytically active PSA by catalytic hK2 (6), which suggests that hK2 may be a physiological activator of PSA (7).
Activation of pro-MMP-2 consists of various overlapping processes, involving a complex formation that consists of the zymogen MMP-2, MT1-MMP, and TIMP-2.
This leads to production of the zymogen interleukin 1 beta (IL-1[beta]), which is proteolytically processed by caspase-1, rendering it biologically active.
In addition, we analyzed other structural aspects including the position of conserved residues and the cleavage site of the zymogen and presented a preliminary phylogenetic analysis of selected members of this subfamily.