zymogen


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Related to zymogen: zymogen granules

zymogen

 [zi´mo-jen]
an inactive precursor that is converted into an active enzyme by action of an acid or another enzyme or by other means; a proenzyme. adj., adj zymogen´ic.

pro·en·zyme

(prō-en'zīm),
The precursor of an enzyme, requiring some change (usually the hydrolysis of an inhibiting fragment that masks an active grouping) to render it active; for example, pepsinogen, trypsinogen, profibrolysin.
Synonym(s): zymogen

zymogen

(zī′mə-jən)
n.

zymogen

an inactive precursor that is converted into an active enzyme by action of an acid, another enzyme, or other means.

pro·en·zyme

(prō-en'zīm)
The precursor of an enzyme, requiring some change (usually the hydrolysis of an inhibiting fragment that masks an active grouping) to render it active, e.g., pepsinogen, trypsinogen, profibrinolysin.
Synonym(s): zymogen.

zymogen

The inactive protein precursor of an ENZYME.

zymogen

an inactive precursor of an enzyme, particularly those concerned with protein digestion, for example, PEPSINOGEN and TRYPSINOGEN. Zymogens require ACTIVATION ENERGY to become functional.

zymogen

an inactive precursor that is converted into an active enzyme by action of an acid or another enzyme or by other means; a proenzyme.

zymogen cells
the secretory cells that secrete the zymogens.
zymogen granules
contained in the cytoplasm of the secretory cells in the relevant gland. Contain the zymogen.
References in periodicals archive ?
Another protective mechanism to prevent the premature activation of trypsinogen to trypsin inside the pancreatic duct is rapidly sweeping out zymogens from the pancreas.
Autoantibodies to GP2, the major zymogen granule membrane glycoprotein, are new markers in Crohn's disease.
These are large, polygonal cells with abundant and lightly basophilic and granular cytoplasm that contains dense, blue-purple, fine to coarse zymogen granules (figure 2).
The matrix metalloproteinases are secreted in a latent zymogen form requiring extracellular activation, after which they are capable of degrading virtually all components of the extracellular matrix.
The protein is produced in the liver as a zymogen and becomes activated upon propeptide cleavage.
zymogen granules), and segregated from cellular componenets that can break down other cellular components (i.
In the example described here, an RNase A enzyme is converted into a zymogen by adding to the enzyme a bridge of amino acids linking the amino and carboxyl termini of the enzyme.
Enzymes that digest proteins could potentially be harmful to the pancreatic cells themselves, so these enzymes are synthesized and stored until needed within the cells as protectively coated zymogen granules.
These bodies are bluish pink in adjacent sections stained with hematoxylin and eosin and presumably are the zymogen granules released from secretory cells during food processing in this tissue.
Pepsinogen is the zymogen (precursor) of the protein-digesting enzyme, pepsin.
Protein C is a serine protease blood coagulation factor that circulates as an inactive zymogen and is activated by thrombin during blood coagulation to form activated protein C (APC).
Each acinus consists of pyramidal cell clusters with many eosinophilic zymogen granules in their apical regions.