zuclopenthixol


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zuclopenthixol

A thioxanthene antipsychotic drug used to treat SCHIZOPHRENIA and other psychotic disorders. A brand name is Clopixol.
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All patients had been using dopamine receptor antagonist medications (quetiapine, olanzapine, clozapine, zuclopenthixol or amisulpride) before the onset of akathisia; three patients were also using selective serotonin reuptake inhibitors (SSRIs); and one patient was on valproic acid treatment.
Hence, the authors recommend the use of long-lasting depot antipsychotic injections (e.g., Zuclopenthixol Decanoate) to stabilise their mood and reduce impulsivity, the risk of overdoses, pseudo-psychotic symptoms and command hallucinations leading to deliberate self-harm.
Zuclopenthixol resolved the psychiatric symptoms and the patient was referred to the hepatology department.
Due to psychomotor agitation and hallucinations, intramuscular injection of zuclopenthixol acetate 50 mg/mL was applied on the second and fifth day of his admission.
Clozapine monotherapy and zuclopenthixol LAI were similarly effective, with each conferring a 47% reduction in rehospitalization risk, compared with periods off therapy.
One RCT (Zhu 2010) did not report details of APs use, but the remaining RCTs (Castro 2011; Shamir 2000; Shamir 2001) reported using a range of APs including levopromazine, haloperidol, clozapine, aripiprazole, olanzapine, quetiapine, risperidone, perphenazine, zuclopenthixol and chlorpromazine.
A neuroleptic malignant syndrome was reported due to the exposure of a typical antipsychotic, zuclopenthixol (Table 4).
A limited number of patients switched from a typical to an atypical antipsychotic or were given exceptionally a typical antipsychotic during hospitalization: one patient received perphenazine (6 mg/day) (1/184; 0.54%), two patients were receiving pimozide (one at 2 mg/day and the second one at 4 mg/day) (2/184; 1.0%), two patients received promazine (50 mg/day and 240 mg/day, resp.) (2/184; 1.0%), and one patient was given zuclopenthixol (60 mg/day) (1/184; 0.54%).
A literature review identified Amisulpride, Flupenthixol, Haloperidol, Levopromazine, Sulpiride, Thioridazine, Zuclopenthixol and second generation antipsychotics at higher doses (Aripiprazole, Olanzapine, Risperidone) as high risk of inducing Parkinson symptoms.
Flupenthixol Decanoate (Fluanxol) or Zuclopenthixol Decanoate (Clopixol) were the second antipsychotics used in those that were treated with two antipsychotics.
During the second period of hospitalistion at the Tranwell Unit, Colin was sectioned for a period of six months and was given antipsychotic drug zuclopenthixol, which the inquest heard can have, in rare circumstances, the side effect of venous thromboembolism.
Antipsychotic medication Drug substance Atypical Amisulpride Aripiprazole Clozapine Olanzapine Paliperidone Quetiapine Risperidone Sertindole Zotepine Typical Perphenazine Benperidol Chlorpromazine Chlorprothixene Droperidol Flupentixol Fluphenazine Haloperidol Levomepromazine Loxapine Oxypertine Pericyazine Pimozide Promazine Remoxipride Sulpiride Thioridazine Trifluoperazine Trifluperidol Zuclopenthixol GPRD were recorded and collected independently from each other.