A centrally acting skeletal muscle relaxant that is no longer used because of its hepatic toxicity.
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Hepatoprotective activity was determined on the basis of their effects on parameters like hexobarbitone sleep time, zoxazolamine paralysis time, bromsulfalein clearance, serum transaminases (GPT, GOT), and serum bilirubin.
Cyp1a2(-/-) mice metabolize zoxazolamine, caffeine, and phenacetin less extensively than Cyp1a2(+/+) wild-type mice and are more susceptible to some aspects of toxicity of these drugs (Liang et al.
In vivo metabolism of hexobarbital and zoxazolamine. Drug Metab Dispos 1984;12:582-7.