Expression of zonula
occludens and adherens junctional
Negative mean Positive mean Negative SE Positive SE Cc 27.500 35.292 3.416 3.375 ZOT 29.375 35.318 4.324 3.505 ETBF 33.685 34.167 3.126 3.333 Fn 35.500 33.380 7.045 3.140 P value P value (adj.) Cc 0.124 0.345 ZOT 0.301 0.749 ETBF 0.919 0.319 Fn 0.793 0.768 Cc, Campylobacter concisus; ZOT, zonula
occludens toxin; ETBF, enterotoxigenic Bacteroidesfragilis; Fn, Fusobacterium nucleatum; SE, standard error; adj., adjusted for age and gender.
Regulation of intercellular tight junctions by zonula
occludens toxin and its eukaryotic analogue zonulin.
McKinney et al., "Altered expression of zonula
occludens-2 precedes increased bloodbrain barrier permeability in a murine model of fulminant hepatic failure," Journal of Investigative Surgery, vol.
At least three transmembrane proteins are required for the assembly of the tight junction complex, including occludin, claudin1, and zonula
Some of these virulence genes include the outer membrane protein (ompW) gene, toxR regulon, Zonula
occludens toxin (zot) gene, pore-forming toxin haemolysin (hlyA), and the heat-stable enterotoxin (stn/sto) gene.
(10,11) TJs exist in several cerebral vascular endothelial cells, such as zonula
occludens-1, occluding, and the claudin family.
capreolata (AFC) in the dinitrobenzenesulphonic acid (DNBS) model of experimental colitis in mice, correlating its potential anti-inflammatory activity to the expression of some of the mediators involved in the intestinal inflammatory response, such as pro-inflammatory cytokines, like IL-6, (IL)-1[beta], TNF-[alpha], IL-12 and IL-17, the chemokine intercellular adhesion molecule (ICAM)-l, the enzymes inducible nitric oxide synthase (iNOS) and the metalloproteinase (MMP)-9, as well as two markers of epithelial integrity in the mucosa, the mucin MUC-2 and the transmembrane protein zonula
Irsogladine maleate counters the interleukinI b- induced suppression in gap-junctional intercellular communication but does not affect the interleukin-lb-induced zonula
occludens protein- I levels in human gingival epithelial cells.
List of Abbreviations AF: Atrial fibrillation APD: Action potential duration CaMKII: [Ca.sup.2+]/calmodulin-dependent protein kinases II Cx43: Connexin 43 CV: Conduction velocity DAD: Delayed afterdepolarization EAD: Early afterdepolarization ICD: Implantable cardioverter defibrillator NCX: [Na.sup.+]/[Ca.sup.2+] exchanger PLB: Phospholamban ROS: Reactive oxygen species RyR: Ryanodine receptor SERCA: Sarco-/endoplasmic reticulum [Ca.sup.2+]-ATPase SCA: Sudden cardiac arrest SCD: Sudden cardiac death TGF-[beta]: Transforming Growth Factor-[beta] VT: Ventricular tachycardia VF: Ventricular fibrillation ZO-1: Zonula