zona fasciculata


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to zona fasciculata: cortisol, zona glomerulosa, zona reticularis

zona

 [zo´nah] (L.)
1. zone.
zona fascicula´ta the thick middle layer of the adrenal gland.
zona glomerulo´sa the outermost layer of the adrenal cortex.
zona ophthal´mica herpetic infection of the cornea.
zona pellu´cida
1. the transparent, noncellular, secreted layer surrounding an ovum.
Zona pellucida. From Applegate, 2000.
2. area pellucida.
zona radia´ta a zona pellucida exhibiting conspicuous radial striations.
zona reticula´ris the innermost layer of the adrenal cortex.
zona stria´ta a zona pellucida exhibiting conspicuous striations.

zo·na fas·ci·cu·la·ta

the layer of radially arranged cell cords in the cortical portion of the suprarenal gland, between the zona glomerulosa and zona reticularis; secretes cortisol and dehydroepiandrosterone.

zo·na fas·ci·cu·la·ta

(zō'nă fash-ik'yū-lā'tă)
The layer of radially arranged cell cords in the cortex of the suprarenal gland, between the zona glomerulosa and zona reticularis; secretes cortisol and dehydroepiandrosterone.
References in periodicals archive ?
Rat adrenal slices exposed to Me[SO.sub.2]-[[sup.14]C]DDE for 24 hr showed very weak labeling of zona fasciculata after 60 weeks of exposure (Figure 4 E,F).
In contrast, microautoradiograms of mouse adrenal slices exposed to o,p'-[[sup.14]C]DDD showed a very weak but selective labeling of zona fasciculata and zona reticularis (data not shown).
Except for a slight swelling of zona fasciculata cells, no obvious histologic changes could be observed after 24 hr of culture of tetracosactide-exposed slices, compared with noncultured slices fixed for histology immediately after slicing (Figure 5 A-B).
Ultrastructural examination of slices fixed immediately after sectioning revealed numerous mitochondria and smooth endoplasmatic reticulum (SER) in zona glomerulosa and zona fasciculata cells.
This observation is particularly important because Me[SO.sub.2]-DDE is activated by CYP11B1, an enzyme residing in the mitochondrial inner membrane of zona fasciculata cells.
The irreversible Me[SO.sub.2]-[[sup.14]C]DDE binding was confined to zona fasciculata, while zona glomerulosa, zona reticularis, and the adrenal medulla were devoid of bound radioactivity (above the background levels).
CYP11B1 catalyzes the last step in this pathway but also, as mentioned, the metabolic activation of Me[SO.sub.2]-DDE in the adrenal zona fasciculata (12,30,31).
Igf1 mRNA levels are very high in the zona fasciculata cells and Igf1 is known to stimulate proliferation and steroidogenesis in human, rat, and bovine adrenocortical cells [39, 43, 44].