Gorgels, "Diagnostic value of zinc protoporphyrin
in a screening strategy for a-thalassemia," European Journal of Haematology, vol.
We required that two a priori criteria be met for inclusion in the meta-analysis: a) sample sizes, means, and SDs were either reported or could be determined for the ALAD1-1 and ALAD1-2/2-2 genotypes; and b) combined with one or more of the following measures--BLL, tibia lead level, trabecular (patella or calcaneus) lead level, zinc protoporphyrin
(ZPP), hemoglobin, serum creatinine, dimercaptosuccinic acid-chelatable lead, and systolic or diastolic blood pressure.
Failure to insert Fe into the protoporphyrin ring results in depressed heme formation and an accumulation of protoporphyrin; this in turn chelates zinc in place of Fe, to form zinc protoporphyrin
Eighty-two low-income minority children aged 9-59 months were assessed to determine hemoglobin, zinc protoporphyrin
(ZPP), iron depletion, and the presence of infection.
The boy's zinc protoporphyrin
level peaked at 556 mM/ M (normal: 25-65 mM/M).
In that situation, some of the newer tests of iron status may be of value in the differentiation of IDA and AI, in particular measurement of serum-soluble transferrin receptors (sTfr) and red cell zinc protoporphyrin
Measurements of transferrin receptor and erythrocyte zinc protoporphyrin
IX (ZnPPIX) concentrations have been suggested as screening tools to detect iron deficiency (1,2).
Previous studies have suggested that [delta]-aminolevulinic acid dehydratase (ALAD) types 1-2 or 2-2 are protective against the toxicity of blood lead (PbB) when zinc protoporphyrin
(ZPP) levels are low because of differential binding of lead in erythrocytes.
Because ceramic glaze can contain lead, a blood sample was obtained to be tested for lead and zinc protoporphyrin
The patient's zinc protoporphyrin
level was 229 [micro]g/dL (normally [is less than] 40 [micro]g/dL).
Measurements of the heme precursors free erythrocyte protoporphyrin (FEP) and erythrocyte zinc protoporphyrin
(ZnP) have also been used for screening purposes.