ZMPSTE24

(redirected from zinc metallopeptidase)

ZMPSTE24

A gene on chromosome 1p34 that encodes a member of the M48A peptidase amily, which is a zinc metalloproteinase involved in the post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A.
 
Molecular pathology
ZMPSTE24 mutations are linked to mandibuloacral dysplasia and restrictive dermopathy.
References in periodicals archive ?
Angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) are zinc metallopeptidases, which are located on the outer membrane of different cells (ectoenzymes).