zinc finger


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Related to zinc finger: Leucine zipper

zinc fin·ger

a zinc-binding domain in a protein structure often seen in certain gene regulatory proteins, for example, transcription factors.
Farlex Partner Medical Dictionary © Farlex 2012
A small tertiary protein structural motif of higher organisms, in which parts of a protein fold around a zinc molecule, acting as a hook to attach activator proteins to DNA; the ZF motif is present in many proteins that regulate expression of eukaryotic genes—e.g., proto-oncogenes, Wilms’ tumour gene, growth signal receptors
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

zinc finger

a finger-like structure that is found in specific DNA binding PROTEINS, where the DNA binding DOMAIN of the protein complexes zinc. Zinc fingers are found in various eukaryotic TRANSCRIPTION factors, which have a role in controlling the transcription of specific GENES.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
Neuromuscular expression of the BTB/POZ and zinc finger protein myoneurin.
(2004) Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d.
The [C.sub.2][H.sub.2] zinc finger transcription factors are usually thought to be involved in plant development and have various adaptive responses to environmental stress [22].
Vermassen et al., "The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion," Molecular Cell, vol.
The DOF domain was truly functioning as Cys2/Cys2-type zinc finger proteins.
Because KLF6-SV1, lacks the binding domain DNA, called "zinc fingers", there is no transactivation of p21 and E-cadherin genes, which are required for the KLF6 tumor suppressor function (Narla et al., 2001; DiFeo et al., 2006).
Zinc finger nucleases have revolutionized the field of genome editing by demonstrating the ability to manipulate genomic sites of interest and opened the gates for both basic and applied research.
The DNA-binding domain of the prokaryotic [Cys.sub.2][His.sub.2] zinc finger protein Ros (Ros87) folds in a domain that is structurally different and significantly larger than its eukaryotic counterpart.
Wanget al., "Genomic editing of the HIV1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases," Molecular Therapy, vol.
The zinc finger (ZNF) protein family is known to exist in almost all eukaryotes, and constitutes a major subset of eukaryotic transcription factors (Seetharam and Stuart et al., 2013).
When taken together, two DNA Markers--methylation of the vav guanine nucleotide exchange factor 3 (VAV3) and zinc finger protein 682 (ZNF682) genes--were 100% specific and 100% sensitive for Barrett's esophagus, with an AUC of 1.0.
Reverse transcription polymerase chain reaction (RT-PCR) approach was used to study the effect of GA-mediated seed priming on the expression of two stress responsive genes, OsZat 12-1 (LOC_Os01g62130 also called ZOS1-14 - C2H2 zinc finger protein) and OsZat 12-9 (LOC_Os01g62190 also called ZOS1-15 - C2H2 zinc finger protein).

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