zinc finger


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Related to zinc finger: Leucine zipper

zinc fin·ger

a zinc-binding domain in a protein structure often seen in certain gene regulatory proteins, for example, transcription factors.

zinc finger

a loop of a transcription factor that is stabilized by a zinc ion coordinated with histidine nitrogen atoms or cysteine sulfur atoms at critical junctures in a protein. It is an important step in the cloning and sequencing of human general transcription factors because individual proteins appear to be involved in the regulation of transcription and in RNA transport.
A small tertiary protein structural motif of higher organisms, in which parts of a protein fold around a zinc molecule, acting as a hook to attach activator proteins to DNA; the ZF motif is present in many proteins that regulate expression of eukaryotic genes—e.g., proto-oncogenes, Wilms’ tumour gene, growth signal receptors

zinc finger

a finger-like structure that is found in specific DNA binding PROTEINS, where the DNA binding DOMAIN of the protein complexes zinc. Zinc fingers are found in various eukaryotic TRANSCRIPTION factors, which have a role in controlling the transcription of specific GENES.
References in periodicals archive ?
2] type zinc finger proteins initially considered restrained to the eukaryotes, the first prokaryotic [C.
Keep your fingers off my DNA: protein-protein interactions mediated by C2H2 zinc finger domains.
EVI-1 zinc finger protein works as a transcriptional activator via binding to a consensus sequence of GACAAGATAAGATAAN1-28 CTCATCTTC.
Characterization of multidrug resistance 1a/P-glycoprotein knockout rats generated by zinc finger nucleases.
The zinc finger protein Zat12 is required for cytosolic ascorbate peroxidase 1 expression during oxidative stress in Arabidopsis.
Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-a locus due to a variant t (11; 17) translocation associated with acute promyelocytic leukemia.
98 in male probands and was 0 in female carriers, indicating that these zinc finger genes could be used as a reliable indicator of the fractional cffDNA concentration in the subsequent study using maternal plasma (see online Supplemental Table 4).
The UC Santa Cruz team developed a novel assay to test whether a particular KRAB zinc finger protein could shut down certain jumping genes.
To verify the reliability of our results we also searched several other databases including EMBI-EBI Pfam and SMART using the terms CCCH zinc finger Danio" or C3H zinc finger Danio.
To artificially confer this invulnerability, June's team removed T cells from 12 HIV-infected patients who were taking standard antiviral drugs and used zinc fingers to delete the doorway receptor gene.
Dana Carroll of the University of Utah recognized that zinc finger nucleases, engineered proteins reported by colleagues at Johns Hopkins University in 1996, could be used as a programmable gene-targeting tool.
Madam, Kruppel-like factor 6 (KLF6) is a zinc finger transcription factor that induces apoptosis in cancer cells leading to suppression of tumour growth.

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