zileuton


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zileuton

 [zi-loo´ton]
an inhibitor of leukotriene formation, used in treatment of asthma; administered orally.

zileuton

(zī-lo͞o′tn)
n.
A drug that inhibits leukotriene formation, used to treat asthma.

A64077

An experimental therapeutic which inhibits the 5-lipoxygenase pathway of arachidonic acid metabolism, which attenuates the bronchoconstriction response in asthmatics to cold air and allergen-induced nasal constriction, a response attributed to the eicosanoids produced by 5-lipoxygenase—e.g., sulfidopeptide leukotrienes, 5-HETE, and leukotriene B4.

zileuton

Zyflo® Clinical medicine An inhibitor of 5-lipoxygenase, an enzyme central to leukotriene synthesis, which mediates inflammatory responses Indications Asthma. See Asthma.

Zileuton (Zyflo)

A medication that interferes with the biosynthetic pathway that produces leukotrienes; used to help prevent asthma attacks.
References in periodicals archive ?
However, Pratico noted that previous work showed zileuton can also impact amyloid.
Compared with untreated animals, tau mice that had received zileuton performed significantly better on the tests.
As a first test of the role of LTs in this process, we treated rat AMs with a combination of the 5-LO inhibitor zileuton (20 [micro]M) and the FLAP inhibitor MK886 (1 [micro]M).
As compounds 8a-b were essentially equipotent with Zileuton (2) and compound (3) (see results of LT inhibition below), analogs of 8b with substituted phenyl were designed and synthesized.
Willemsen, "Zileuton for pruritus in Sjoogren-Larsson syndrome: a randomized doubleblind placebo-controlled crossover trial," Acta Dermato Venereologica, vol.
Taken orally, zileuton inhibits the 5-LO enzyme, which would otherwise catalyze the formation of leukotrienes from arachidonic acid.
Different treatment modalities like cryotherapy, scarification, topical and systemic steroids, antimalarials, chlorambucil, ciclosporin, dapsone, etretinate, fumaric acid esters, isotretinoin, niacinamide, pentoxifylline, photo(chemo)therapy, potassium iodide, zileuton (a 5-lipoxygenase inhibitor), vitamin E have been tried with variable responses.
Rodrigues, "Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, A 5-lipoxygenase inhibitor," Drug Metabolism and Disposition, vol.
Among known inhibitors, only the antiasthmatic drug Zileuton (1, Figure 1) is approved for human use as the racemic mixture [2,18].