zileuton

[zi-loo´ton]

an inhibitor of leukotriene formation, used in treatment of asthma; administered orally.

zileuton

(zī-lo͞o′tn)

A drug that inhibits leukotriene formation, used to treat asthma.

A64077

An experimental therapeutic which inhibits the 5-lipoxygenase pathway of arachidonic acid metabolism, which attenuates the bronchoconstriction response in asthmatics to cold air and allergen-induced nasal constriction, a response attributed to the eicosanoids produced by 5-lipoxygenase—e.g., sulfidopeptide leukotrienes, 5-HETE, and leukotriene B4.

zileuton

Zyflo^® Clinical medicine An inhibitor of 5-lipoxygenase, an enzyme central to leukotriene synthesis, which mediates inflammatory responses Indications Asthma. See Asthma.

Zileuton (Zyflo)

A medication that interferes with the biosynthetic pathway that produces leukotrienes; used to help prevent asthma attacks.

Mentioned in: Leukotriene Inhibitors

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References in periodicals archive ?

However, Pratico noted that previous work showed zileuton can also impact amyloid.

Old asthma drug shows potential against Alzheimer's

Compared with untreated animals, tau mice that had received zileuton performed significantly better on the tests.

Researchers Reverse Cognitive Impairments in Mice with Dementia

Sustained-release hydrophilic matrix tablets of zileuton: formulation and in vitro/in vivo studies.

Development, Internal and External Validation of Naproxen Sodium Sustained Release Formulation: an Level A In Vitro-In Vivo Correlation/Naproksen Sodyum Sureli Serbest Formulasyonun Gelistirilmesi, Ic ve Dis Olarak Dogrulamasi: Bir Duzey A In Vitro-In Vivo Korelasyon

As a first test of the role of LTs in this process, we treated rat AMs with a combination of the 5-LO inhibitor zileuton (20 [micro]M) and the FLAP inhibitor MK886 (1 [micro]M).

Short-Term Regulation of Fc[gamma]R-Mediated Phagocytosis by TLRs in Macrophages: Participation of 5-Lipoxygenase Products

As compounds 8a-b were essentially equipotent with Zileuton (2) and compound (3) (see results of LT inhibition below), analogs of 8b with substituted phenyl were designed and synthesized.

New Caffeic Acid Phenylethyl Ester Analogs Bearing Substituted Triazole: Synthesis and Structure-Activity Relationship Study towards 5-Lipoxygenase Inhibition

Effect of zileuton in radicular pain induced by herniated nucleus pulposus in rats.

Evaluation of analgesic, anti-inflammatory, and antipyretic activity of leukotriene receptor antagonist-montelukast: An experimental study

Willemsen, "Zileuton for pruritus in Sjoogren-Larsson syndrome: a randomized doubleblind placebo-controlled crossover trial," Acta Dermato Venereologica, vol.

Atypical Presentation of Sjogren-Larsson Syndrome

Taken orally, zileuton inhibits the 5-LO enzyme, which would otherwise catalyze the formation of leukotrienes from arachidonic acid.

Application of nonsteroidal agents

Different treatment modalities like cryotherapy, scarification, topical and systemic steroids, antimalarials, chlorambucil, ciclosporin, dapsone, etretinate, fumaric acid esters, isotretinoin, niacinamide, pentoxifylline, photo(chemo)therapy, potassium iodide, zileuton (a 5-lipoxygenase inhibitor), vitamin E have been tried with variable responses.

A case of childhood recalcitrant granuloma annulare successfully treated with topical tacrolimus

Rodrigues, "Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, A 5-lipoxygenase inhibitor," Drug Metabolism and Disposition, vol.

Effect of inhaling Cymbopogon martinii essential oil and geraniol on serum biochemistry parameters and oxidative stress in rats

Among known inhibitors, only the antiasthmatic drug Zileuton (1, Figure 1) is approved for human use as the racemic mixture [2,18].

Clicked cinnamic/caffeic esters and amides as radical scavengers and 5-lipoxygenase inhibitors

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