zebra body

ze·bra bod·y

metachromatically staining membrane-bound granules, measuring 0.5-1 mcm in diameter and containing lamellae with a 5.8 nm spacing, reported in Schwann cells and macrophages of patients suffering from metachromatic leukodystrophy.
A descriptive term for a lysosome containing broad transversely-stacked myelinoid membranes, an ultrastructural finding typical of certain lysosomal storage diseases, found in neurons, Schwann cells, macrophages, smooth muscle cells, endothelial cells, pericytes, glomerular epithelial cells, hepatocytes, and other cells. Zebra bodies classically occur in Fabry’s disease, but are seen in Niemann-Pick disease, Landing’s disease, Sandhoff’s disease, mucopolysaccharidoses—e.g., Hurler syndrome—myelinopathy, phenylketonuria, and Tay-Sachs disease