zalcitabine


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zalcitabine

 [zal-si´tah-bēn]
a nucleoside analogueantiretroviral agent that inhibits the action of reverse transcriptase; used in the treatment of human immunodeficiency virus (HIV) infection, administered orally.

zalcitabine

(zăl′sĭ-tə-bīn′)
n.
A nucleoside analog antiviral drug that inhibits the replication of retroviruses such as HIV by interfering with the enzyme reverse transcriptase. Also called ddC.

zalcitabine

ddC, Hivid AIDS A purine analogue that inhibits HIV reverse transcriptase; it is similar didanosine vis-á-vis survival, progression, CD4 count, adverse effects, efficacy. See Didanosine, Reverse transcriptase inhibitor. Cf Protease inhibitor.

zalcitabine

A REVERSE TRANSCRIPTASE inhibitor drug used in combination with other drugs to treat AIDS. A brand name is Hivid.
References in periodicals archive ?
It dates back at least to the dawn of HAART, when German researchers offered results on nanoparticle porters of saquinavir and zalcitabine. (56) Since then, other scientists have loaded nanoparticles with zidovudine, (57-61) didanosine, (62,63) stavudine, (64) lamivudine, (57) delavirdine, (64) efavirenz, (65-67) indinavir, (68,69) ritonavir (67,70) and lopinavir.
[5] Nonstandard abbreviations: NRTI, nucleoside reverse transcriptase inhibitor; mtDNA, mitochondrial DNA; PBMC, peripheral blood mononuclear cell; nDNA, nuclear DNA; NASBA, nucleic acid sequence-based amplification; AZT, zidovudine; 3TC, lamivudine; IDV, indinavir; d4T stavudine; ddI, didanosine; ACTG, AIDS Clinical Trial Group; FCS, fetal calf serum; DMSO dimethyl sulfoxide; and ddC, zalcitabine. Table 1.
Arons, we classified combination drug therapy used in the Florida Medicaid program into two groups: (i) two nucleoside analog drugs, including zidovudine (azt), didanosine (ddi), zalcitabine (ddc), stavudine (d4t), and lamivudine (3tc); (ii) one protease inhibitor and a pair of nucleoside analogs.
Currently available anti-HIV drugs Protease Inhibitors Nucleotide Reverse Agenerase (generic name: amprenavir) Transcriptase Inhibitor Crixivan (indinavir) Viread (tenofovir, PMPA) Fortovase (saquinavir) Kaletra (lopinavir plus ritonavir) Nucleoside Reverse Norvir (ritonavir) Transcriptase Inhibitors Viracept (nelfinavir) Combivir (AZT plus 3TC) Epivir (lamivudine, also Nonnucleoside Reverse known as 3TC) Transcriptase Inhibitors Hivid (zalcitabine, ddC) Rescriptor (delavirdine) Retrovir (zidovudine, AZT) Sustiva (efavirenz) Trizivir (abacavir plus AZT plus 3TC) Viramune (nevirapine) Videx (didanosine, ddl) Zerit (stavudine, d4T) Ziagen (abacavir)
Zalcitabine, didanosine and abacavir can also select for this mutation.
The agents in this class include: zidovudine (Retrovir[R]), didanosine (Videx[R]), zalcitabine (Hivid[R]), stavudine (Zerit[R]), lamivudine (Epivir[R]), lamivudine/ zidovudine (Combivir[R]), and the newest NRTI, abacavir (Ziagen[R]).
These expensive drugs include Ziovudine (AZT), Zalcitabine (ddc), Didanosine (ddi), Stavudine (d4t), Nevirapine, Lamivudine 3TC, Saquinavir Mesylate, Indinavir Sulphate, and Ritonavir (Fishel et al, 1996).
The other class of antiretroviral agents available in the United States--nucleoside reverse transcriptase inhibitors (NRTIs) (zidovudine, didanosine, zalcitabine, stavudine, lamivudine, and the new drug abacavir [2]--are not metabolized by CYP450.
The patient's medications on admission included zalcitabine, lamivudine, saquinavir, trimethoprim/ sulfamethoxazole, clindamycin, ciprofloxacin, ganciclovir, senna, naproxen, beclomethasone dipropionate, oxymetazoline HCl, morphine, potassium chloride, warfarin, and zolpidem.
Generic Name Recommended Dosage Didanosine (ddi) If >60 kg: 200 mg bid If <60 kg: 125 mg bid Lamivudine (3TC) If <50 kg: 2 mg/kg bid If >50 kg: 150 mg bid Stavudine (d4T) If >60 kg: 40 mg bid If <60 kg: 30 mg bid Zalcitabine (ddC) 0.75 mg bid Zidovudine (AZT) 200 mg bid or 300 mg bid Lamivudine/ 150 mg/300 mg bid zidovudine (Combivir) Abacavir (Ziagen) 300 mg bid Generic Name Adverse Side Effects Didanosine (ddi) Pancreatitis, peripheral neuropathy, nausea, and diarrhea Lamivudine (3TC) Minimal toxicities Stavudine (d4T) Peripheral neuropathy Zalcitabine (ddC) Peripheral neuropathy, stomatitis Zidovudine (AZT) Anemia, neutropenia, Gl disturbances, headache, insomnia, and asthenia Lamivudine/ Headache, nausea, fatigue, diarrhea, zidovudine and nasal congestion.
* Zalcitabine (ddC, Dideoxycytidine, HIVID), Hoffmann-La Roche
Antiretroviral utilization was defined as self-reported use of zidovudine, didanosine, or zalcitabine. Similarly, PCP medication use was derived from a participant's report of using sulfamethoxazole-trimethoprim, pentamidine, dapsone, or pyrimethamine.