yeast artificial chromosomes

yeast ar·ti·fi·cial chro·mo·somes (YAC),

yeast DNA sequences that have incorporated into them large foreign DNA fragments; the recombinant DNA is then introduced into the yeast by transformation; the use of yeast artificial chromosomes permits the cloning of large genes with their flanking regulatory sequences.
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References in periodicals archive ?
The widespread use of yeast artificial chromosomes as cloning vectors, has created a demand for reliable method to recover intact chromosomal DNA from preparative pulsed field gels.
(In 1996 Resnick, with NIEHS colleagues Vladimir Larionov and Natalya Kouprina, perfected a method using yeast artificial chromosomes, or YACs, for the specific isolation of entire human genes.) In another, changes are introduced into homologous genes or cloned genes in model systems.
A DNA contig of this region spanning 2,400 kb was constructed from large-capacity yeast artificial chromosomes and P1 bacteriophage clones (76).
Although investigators have made yeast artificial chromosomes for more than a decade (SN: 6/5/93, p.