xeroderma


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Related to xeroderma: ichthyosis

xeroderma

 [ze″ro-der´mah]
excessive dryness of the skin, a mild form of ichthyosis.
xeroderma pigmento´sum a rare and often fatal pigmentary and atrophic disease in which the skin and eyes are extremely sensitive to light. It begins in childhood and progresses to early development of excessive freckling, telangiectases, keratoses, papillomas, carcinoma, and melanoma. Ocular symptoms include photophobia, opacities, and tumors. It is inherited as an autosomal recessive trait involving a defect in the enzymes active in the repair of DNA damaged by ultraviolet irradiation. Subtypes of this disorder have been identified by the capacity for DNA repair. Total protection from sunlight prevents the development of lesions.

xe·ro·der·ma

(zē'rō-der'mă),
A mild form of ichthyosis characterized by excessive dryness of the skin due to slight thickening of the horny layer and diminished water content of the stratum corneum from decreased perspiration or exposure to wind, or low humidity; seen with aging, atopic dermatitis, vitamin A deficiency, etc.
[xero- + G. derma, skin]

xeroderma

/xe·ro·der·ma/ (zēr″o-der´mah) a mild form of ichthyosis, marked by a dry, rough, discolored state of the skin.xerodermat´ic
xeroderma pigmento´sum  a rare pigmentary and atrophic autosomal recessive disease in which extreme cutaneous sensitivity to ultraviolet light results from an enzyme deficiency in the repair of DNA damaged by ultraviolet light. It begins in childhood, with early development of excessive freckling, telangiectases, keratomas, papillomas, and malignancies in sun-exposed skin, severe opthalmologic abnormalities, and, in some cases, neurological disorders.

xeroderma

(zîr′ō-dûr′mə) also

xerodermia

(-mē-ə)
n.
Excessive or abnormal dryness of the skin, as in ichthyosis.

xeroderma

[zir′ədur′mə]
Etymology: Gk, xeros, dry, derma skin

xeroderma

Dry skin, see there.

xe·ro·der·ma

, xerodermia (zēr'ō-dĕr'mă, -mē-ă)
A mild form of ichthyosis characterized by excessive dryness of the skin due to slight increase of the horny layer and diminished water content of the stratum corneum from decreased perspiration, wind, or low humidity; seen with aging, atopic dermatitis, and vitamin A deficiency.
[xero- + G. derma, skin]

xeroderma

Dryness of the skin.

xe·ro·der·ma

, xerodermia (zēr'ō-dĕr'mă, -mē-ă)
Mild form of ichthyosis characterized by excessive dryness of skin due to slight thickening of horny layer and diminished water content of stratum corneum due to decreased perspiration or exposure to wind, or low humidity; associated with aging, atopic dermatitis, and vitamin A deficiency.
[xero- + G. derma, skin]

xeroderma

a mild form of ichthyosis; excessive dryness of the skin.
References in periodicals archive ?
Patients with the a variant form of Xeroderma Pig-mentosum (XPV) have a deficiency in hPoln and are very sensitive to sunlight and develop skin cancer in their early ages.
For the first time in 1969, the crucial role played by DNA repair in preventing cancer was conclusively demonstrated by Cleaver (2), when he identified a defect in the pathway of excision repair among patients with Xeroderma Pigmentosum.
33) It has been associated with systemic conditions such as FAM-M syndrome, xeroderma pigmentosum and neurofibromatosis.
With this screen, a little girl, who has the rare condition xeroderma pigmentosum, can play outside in her toy car without having to wear clothing to protect her from the sun.
First, oral retinoids have been used with great success to prevent skin cancers in populations who are at high-risk, such as patients with xeroderma pigmentosum and immunosuppressed patients.
Akan M, Yildirim S, Avci G, Akoz T: Xeroderma pigmentosum with a giant cutaneous horn.
Bloom syndrome, Rothmund-Thomson syndrome, xeroderma pigmentosum, etc.
The Bowman-Birk protease inhibitor enhances clonogenic cell survival of ionizing radiation-treated nucleotide excision repair-competent cells but not of xeroderma pigmentosum cells.
ISLAMABAD, July 22, 2010 (Balochistan Times): On the directives of Prime Minister Syed Yousuf Raza Gilani, seven children diagnosed with a rare disease Xeroderma Pigmentosa have been sifted to Quetta from district Kachhi and now being treated by dermatologists of Balochistan Health Department.
One attendee asked about the cost of clothes and equipment for the protection of children affected with Xeroderma pigmentosum ("moon children").
Algunas de ellas son: sindrome de nevus displasico, xeroderma pigmentosum, medicamentos fotosensibilizantes y lupus eritematoso, el cual podria agravarse.
Dr Fazeela Abbasi, adviser to the ministry of health, told the media in Islamabad that the children were suffering from xeroderma pigmentosum, an extremely rare autosomal recessive genetic disorder of DNA repair in which the ability to repair damage caused by ultraviolet light was deficient.