xeroderma


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Related to xeroderma: ichthyosis

xeroderma

 [ze″ro-der´mah]
excessive dryness of the skin, a mild form of ichthyosis.
xeroderma pigmento´sum a rare and often fatal pigmentary and atrophic disease in which the skin and eyes are extremely sensitive to light. It begins in childhood and progresses to early development of excessive freckling, telangiectases, keratoses, papillomas, carcinoma, and melanoma. Ocular symptoms include photophobia, opacities, and tumors. It is inherited as an autosomal recessive trait involving a defect in the enzymes active in the repair of DNA damaged by ultraviolet irradiation. Subtypes of this disorder have been identified by the capacity for DNA repair. Total protection from sunlight prevents the development of lesions.

xe·ro·der·ma

(zē'rō-der'mă),
A mild form of ichthyosis characterized by excessive dryness of the skin due to slight thickening of the horny layer and diminished water content of the stratum corneum from decreased perspiration or exposure to wind, or low humidity; seen with aging, atopic dermatitis, vitamin A deficiency, etc.
[xero- + G. derma, skin]

xeroderma

(zîr′ō-dûr′mə) also

xerodermia

(-mē-ə)
n.
Excessive or abnormal dryness of the skin, as in ichthyosis.

xeroderma

Dry skin, see there.

xe·ro·der·ma

, xerodermia (zēr'ō-dĕr'mă, -mē-ă)
A mild form of ichthyosis characterized by excessive dryness of the skin due to slight increase of the horny layer and diminished water content of the stratum corneum from decreased perspiration, wind, or low humidity; seen with aging, atopic dermatitis, and vitamin A deficiency.
[xero- + G. derma, skin]

xeroderma

Dryness of the skin.

xe·ro·der·ma

, xerodermia (zēr'ō-dĕr'mă, -mē-ă)
Mild form of ichthyosis characterized by excessive dryness of skin due to slight thickening of horny layer and diminished water content of stratum corneum due to decreased perspiration or exposure to wind, or low humidity; associated with aging, atopic dermatitis, and vitamin A deficiency.
[xero- + G. derma, skin]
References in periodicals archive ?
Xeroderma pigmentosum-Cockayne syndrome is a rare clinically overlapping genetic disorder characterized by somatic and neurological abnormalities of Cockayne syndrome and skin and eye manifestations of Xeroderma pigmentosum.7 In making the diagnosis for this patient, the clinical features were evidently indicative of Cockayne syndrome.
For example, atopic dermatitis, xeroderma, contact dermatitis, seborrheic dermatitis, pruritus, callus, and bacterial and fungal infections were found more commonly in autumn and winter months, whereas acne vulgaris, urticaria, contact dermatitis, insect bite, verruca, and miliaria were found more commonly in spring and summer months in our study.
Sancar, "Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties," Molecular and Cellular Biology, vol.
Carell, "Molecular mechanisms of xeroderma pigmentosum (XP) proteins," Quarterly Reviews of Biophysics, vol.
A commercial Xeroderma Pigmentosum Next Generation Sequencing panel including the genes DDB2, ERCC2, ERCC3, ERCC4, ERCC5, POLH, XP-A, and XPC revealed a homozygous germline sequence variant designated c.547A>T in the XPC gene, which was confirmed by Sanger sequencing.
For red light irradiation, prostate cancer, breast cancer, brain cancer, lung cancer, Wilms' tumor, Fanconi anemia, Barrett's esophagus/esophageal adenocarcinoma, xeroderma pigmentosum, medulloblastoma, epidermodysplasia verruciformis, colorectal cancer, and endometrial cancer in gastrointestinal stromal tumor could develop in nondiabetic patients (Table 4).
Plus de 180 enfants atteints de Xeroderma Pigmentosum, connue sous le nom les [beaucoup moins que] enfants de la lune [beaucoup plus grand que], pris en charge par l'association Essaada (le bonheur) au niveau de la wilaya d'Alger, beneficient durant la saison estivale de sorties nocturnes vers les plages et piscines de la capitale, a indique le vice-president de l'association, Saadi Lahri.
Xeroderma pigmentosum was seen in an 11-year-old black boy who developed squamous cell carcinoma (SCC) on the scalp (Fig.
[sup][18] Different diseases, such as xeroderma pigmentosum [sup][19] and dermatopathia pigmentosa reticularis, [sup][20] need to be distinguished in clinical practice.
Xeroderma pigmentosum group A (XPA) is a genetic disorder in DNA nucleotide excision repair (NER) with severe neurological disorders, in which oxidative stress and disturbed melatonin metabolism may be involved.
Besides ACD, there are many other diseases with the characteristics of cutaneous dyschromia, includes dyschromatosis universalis hereditaria, xeroderma pigmentosum and poikiloderma-like amyloidosis.