xenotransplantation


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xenotransplantation

(zĕn′ə-trăns′plăn-tā′shən, zē′nə-)
n.
The surgical transfer of cells, tissues, or especially whole organs from an organism of one species to an organism of a different species.
The transplantation of an organ from a lower mammal—e.g., baboon, pig—to a higher mammal—e.g., human

xenotransplantation

Xenogeneic transplantation Transplant biology The transplantation of cells or tissues from one species to another; the use of live, nonhuman animal cells, tissues, and organs in humans. See Xenograft.

xenotransplantation

Transplantation of organs from animals, usually transgenic animals, especially pigs, specifically engineered for the purpose. Until recently, no transplanted pig organ had survived for more than a month. But advances in the development of new immunosuppressive agents against xenografts and the identification of the main target for human xenoreactive (anti-pig) antibodies have extended this period to an average of 76 days. Precautions can also be taken against virus transmission. The future for xenotransplantation seems bright.
References in periodicals archive ?
Guidance for industry: source animal, product, preclinical, and clinical issues concerning the use of xenotransplantation products in humans.
Lanza acknowledge, the earliest attempts at xenotransplantation date back to the seventeenth century (27-28).
Wood et al., "No in vivo infection of triple immunosuppressed non-human primates after inoculation with high titers of porcine endogenous retroviruses," Xenotransplantation, vol.
Xenotransplantation also raises other ethical questions in relation to the wider community.
It would be essential, the document says, for xenotransplantation research participants to understand that lifelong surveillance is critical, and that failure to comply could, in some cases, force legal action.
In the simulated negotiation for xenotransplantation, stakeholders were X-Gen (the biotechnology company who had developed the procedure), the National Government, the World Health Organization, the Animal Rights Coalition (a non-governmental organization), and the Patient Rights' Organization (a second NGO).
Well, Xenotransplantation offers an almost unlimited supply of organs and it also has the potential to assist patients suffering from many other illnesses, such as diabetes, Alzheimer's disease, Parkinson's disease and haemophilia.
The process, known as xenotransplantation, has been stalled because the human immune system recognises the animal organ and rejects it.
California Loma Linda University Medical Centre surgeon Leonard Bailey, however, suggested xenotransplantation, the technical term for organ transplant between species.
It still hopes to sell off its xenotransplantation arm, which was responsible for the birth of ``double-knockout'' pigs last month.
Surgeons used xenotransplantation - the use of cells, tissues and organs from different species - to ``replumb'' the heart of three-year-old Rhiannon Astley, cousin of '80s pop star Rick.