xenobiotics


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xenobiotics,

n.pl potentially harm-ful, lipid-soluble chemicals that are foreign to the human body.

xenobiotics

foreign organic compounds not produced in metabolism.
References in periodicals archive ?
Parts 6 and 7 cover the inter-individual and intra-individual factors that influence drug metabolism, starting with an introduction to evolutionary events leading to species differences in the metabolism of xenobiotics and to polymorphisms within a particular species.
Key words: adjuvants, aromatase, endocrine disruption, glyphosate, herbicide, human JEG3 cells, placenta, reductase, Roundup, xenobiotic.
Relative potency of xenobiotic estrogens in an acute in vivo mammalian assay.
It would be equally surprising if antagonism of SXR did not alter the normal physiologic response to steroids, xenobiotics, and dietary compounds, as has been demonstrated for activation of SXR in promoting drug-drug interactions [reviewed by Dussault and Forman (2002); Willson and Kliewer (2002); Xie and Evans (2001)].
Accurate and frequently updated information is needed on children's diets at different ages and on the concentrations of xenobiotics in those diets.
Measuring internal levels of xenobiotics around the time of conception will provide a much more realistic picture of the exposure of the embryo at the critical period of conception.
A number of organic and inorganic xenobiotics exert their toxicity via a sequence of mechanisms that relate to redox-related biotransformation (Bagchi et al.
1) Development of integrative, quantitative models of the function of the hypothalamic-pituitary-gonadal or hypothalamic-pituitary-thyroid axis with emphasis on the descriptions of the normal physiological processes and mechanisms of perturbation following exposure to xenobiotics (e.
FIT combines the administration of xenobiotics with the high throughput screening capability of immunoassay to yield a rate measurement that gives medically relevant physiological information regarding organ performance.
Via diet, humans are exposed to a huge variety of xenobiotics, many of which are endocrine active, and our bodies may be well equipped to handle routinely encountered doses of endocrine-active compounds whether from natural or anthropogenic sources (Safe et al.
During Helton's long career in scientific and clinical research, he has been closely involved in both the design and FDA submission of pharmacokinetic, efficacy and safety data of recombinant drugs, synthetic peptides, endogenous products and low molecular weight lipophilic xenobiotics.
At the time, the ramifications of the polymorphism seemed to be limited to populations exposed to a relatively discrete group of xenobiotics.