xanthoma

(redirected from xanthomata)
Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to xanthomata: xanthelasma, malar flush

xanthoma

 [zan-tho´mah]
a papule, nodule, or plaque in the skin due to lipid deposits; it is usually yellow, but may be brown, reddish, or cream colored. Microscopically, the lesions show light cells with foamy protoplasm (foam cells). Xanthomas range in size from tiny pinheads to large nodules, and the shape may be round, flat, or irregular. They are often found around the eyes, the joints, the neck or the palms, or over tendons. Often these lipid deposits are not limited to the skin but are found throughout the body in bones, the heart, blood vessels, liver, and other organs.



The formation of xanthomas may indicate an underlying disease, usually related to abnormal metabolism of lipids, including cholesterol. Abnormally high levels of blood lipids may be found in diabetes mellitus (xanthoma diabeticorum), in diseases of the liver, kidney, and thyroid gland, and in several hereditary metabolic diseases. The excessive lipids carried in the blood may then be deposited as xanthomas. Treatment includes surgery, application of acids directly to the lipid deposits, and management of the disease that causes them.
Legs of a person homozygous for familial hypercholesterolemia, showing multiple xanthomas. From Mueller and Young, 2001.
diabetic xanthoma an eruptive xanthoma associated with diabetes mellitus; when the diabetes is brought under control, the skin lesions disappear.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

xan·tho·ma

(zan-thō'mă),
A yellow nodule or plaque, especially of the skin, composed of lipid-laden histiocytes.
[G. xantho-, blond + G. -oma, tumor]
Farlex Partner Medical Dictionary © Farlex 2012

xanthoma

(zăn-thō′mə)
n. pl. xantho·mas or xantho·mata (-mə-tə)
A yellowish-orange, lipid-filled nodule or papule in the skin, often on an eyelid or over a joint.

xan·thom′a·tous (-thŏm′ə-təs) adj.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

xanthoma

Fatty skin growth Dermatology A yellow-orange lipid-filled papule or plaque located on the skin or tendons, which is common in the general population and Pts with DM, and may be ↑ in various 'lipid disorders–eg, lipoprotein lipase deficiency, abetalipoproteinemia, hypercholesterolemia, hypertriglyceridemia
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

xan·tho·ma

(zan-thō'mă)
A yellow nodule or plaque, especially of the skin, composed of lipid-laden histiocytes.
[G. xantho-, blond + G. -oma, tumor]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

xanthoma

A yellowish or orange mass of fat-filled cells occurring in the skin of people with various disorders of fat metabolism. Also known as generalized XANTHELASMA.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

xanthelasma 

A cutaneous deposition of lipid material that appears in the skin of the eyelids, most commonly near the inner canthi. It appears as a yellowish, slightly elevated area. It is a benign and chronic condition that occurs primarily in the elderly. It may be associated with raised blood cholesterol, high-density lipoprotein and triglyceride levels, leading to heart disease or diabetes. Syn. xanthoma; xanthelasma palpebrarum; xanthoma palpebrarum. See corneal arcus; Hollenhorst's plaque.
Millodot: Dictionary of Optometry and Visual Science, 7th edition. © 2009 Butterworth-Heinemann

xan·tho·ma

(zan-thō'mă)
Yellow nodule or plaque, especially dermatologic, composed of lipid-laden histiocytes.
[G. xantho-, blond + G. -oma, tumor]
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Routinely palpating the Achilles tendons ensures that xanthomata are not missed and also gives one a good appreciation of the range of normality.
Sixteen patients attended the clinic for the first time because of an attack of pancreatitis, 2 children presented with eruptive xanthomata, 1 male infant was diagnosed after death, 1 woman had incidentally discovered hypertriglyceridaemia, 1 boy was diagnosed following a stroke that was attributed to hypertriglyceridaemia, and 8 patients were diagnosed by family screening.
Eruptive xanthomata often precede the abdominal pain, but are an unreliable clinical sign for the diagnosis of LPL deficiency.
The homozygous FH phenotype produces cutaneous and tendinous xanthomata before adolescence, LDL cholesterol >14 mmol/l, very premature coronary disease, and aortic stenosis.
In the FH cohort (whose mean age at presentation was 44 years), 80% had tendon xanthomata, 36% had arcus cornealis, and 14% had xanthelasma.
(1) The heterozygous phenotype is characterised by a personal or family history of premature ischaemic heart disease, tendon xanthomata and elevated plasma low-density lipoprotein (LDL) cholesterol levels (5-12 mmol/l).
Arcus cornealis was present in 36%, and 80% had tendon xanthomata. Xanthelasma was significantly commoner in females (p<0.0001, Fisher's exact test).
There is a marked increase in the prevalence of tendon xanthomata from 12% before the age of 25 years up to 75% by the age of 40 years, and about 90% by the age of 50 years.
There was no difference in the prevalence of xanthelasma at presentation in males and females (p=0.3), but arcus occurred significantly earlier in males (p=0.0001), as did tendon xanthomata (p<0.0001, chi-squared test).
The proband was identified based on the presence of severe hypercholesterolemia and the presence of tendon xanthomata in accordance with established diagnostic criteria (8).
Subject I-1 II-1 II-2 II-3 Age, years 63 29 27 39 Sex F F F F Total cholesterol, mmol/L 7.37 6.53 5.29 7.87 HDL-cholesterol, mmol/L 1.37 1.69 1.44 1.71 Triglycerides, mmol/L 1.08 1.7 0.6 1.33 LDL-C, mmol/L 5.51 4.07 3.58 5.56 apo A-I, g/L 1.36 1.25 1.39 1.63 apo B, g/L 1.68 1.05 0.98 1.48 Tendon xanthomata No No No No CAD No No No No Mutation analysis FDB FH None None II-4 II-5 III-1 III-2 Age, years 43 32 15 14 Sex F M M M Total cholesterol, mmol/L 11.65 7.37 5.39 5.34 HDL-cholesterol, mmol/L 1.51 1.07 0.91 1.31 Triglycerides, mmol/L 1.48 1.17 4.58 0.61 LDL-C, mmol/L 9.47 5.77 3.75 apo A-I, g/L NA (a) 1.1 1.18 1.25 apo B, g/L NA 1.63 1.21 1.05 Tendon xanthomata Yes No No No CAD No No No No Mutation analysis FH/FDB FDB FDB FDB (a) NA, not available.