xanthoma

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xanthoma

 [zan-tho´mah]
a papule, nodule, or plaque in the skin due to lipid deposits; it is usually yellow, but may be brown, reddish, or cream colored. Microscopically, the lesions show light cells with foamy protoplasm (foam cells). Xanthomas range in size from tiny pinheads to large nodules, and the shape may be round, flat, or irregular. They are often found around the eyes, the joints, the neck or the palms, or over tendons. Often these lipid deposits are not limited to the skin but are found throughout the body in bones, the heart, blood vessels, liver, and other organs.



The formation of xanthomas may indicate an underlying disease, usually related to abnormal metabolism of lipids, including cholesterol. Abnormally high levels of blood lipids may be found in diabetes mellitus (xanthoma diabeticorum), in diseases of the liver, kidney, and thyroid gland, and in several hereditary metabolic diseases. The excessive lipids carried in the blood may then be deposited as xanthomas. Treatment includes surgery, application of acids directly to the lipid deposits, and management of the disease that causes them.
Legs of a person homozygous for familial hypercholesterolemia, showing multiple xanthomas. From Mueller and Young, 2001.
diabetic xanthoma an eruptive xanthoma associated with diabetes mellitus; when the diabetes is brought under control, the skin lesions disappear.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

xan·tho·ma

(zan-thō'mă),
A yellow nodule or plaque, especially of the skin, composed of lipid-laden histiocytes.
[G. xantho-, blond + G. -oma, tumor]
Farlex Partner Medical Dictionary © Farlex 2012

xanthoma

(zăn-thō′mə)
n. pl. xantho·mas or xantho·mata (-mə-tə)
A yellowish-orange, lipid-filled nodule or papule in the skin, often on an eyelid or over a joint.

xan·thom′a·tous (-thŏm′ə-təs) adj.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

xanthoma

Fatty skin growth Dermatology A yellow-orange lipid-filled papule or plaque located on the skin or tendons, which is common in the general population and Pts with DM, and may be ↑ in various 'lipid disorders–eg, lipoprotein lipase deficiency, abetalipoproteinemia, hypercholesterolemia, hypertriglyceridemia
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

xan·tho·ma

(zan-thō'mă)
A yellow nodule or plaque, especially of the skin, composed of lipid-laden histiocytes.
[G. xantho-, blond + G. -oma, tumor]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

xanthoma

A yellowish or orange mass of fat-filled cells occurring in the skin of people with various disorders of fat metabolism. Also known as generalized XANTHELASMA.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

xanthelasma 

A cutaneous deposition of lipid material that appears in the skin of the eyelids, most commonly near the inner canthi. It appears as a yellowish, slightly elevated area. It is a benign and chronic condition that occurs primarily in the elderly. It may be associated with raised blood cholesterol, high-density lipoprotein and triglyceride levels, leading to heart disease or diabetes. Syn. xanthoma; xanthelasma palpebrarum; xanthoma palpebrarum. See corneal arcus; Hollenhorst's plaque.
Millodot: Dictionary of Optometry and Visual Science, 7th edition. © 2009 Butterworth-Heinemann

xan·tho·ma

(zan-thō'mă)
Yellow nodule or plaque, especially dermatologic, composed of lipid-laden histiocytes.
[G. xantho-, blond + G. -oma, tumor]
Medical Dictionary for the Dental Professions © Farlex 2012