xanthoma


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to xanthoma: lipoma, verrucous xanthoma

xanthoma

 [zan-tho´mah]
a papule, nodule, or plaque in the skin due to lipid deposits; it is usually yellow, but may be brown, reddish, or cream colored. Microscopically, the lesions show light cells with foamy protoplasm (foam cells). Xanthomas range in size from tiny pinheads to large nodules, and the shape may be round, flat, or irregular. They are often found around the eyes, the joints, the neck or the palms, or over tendons. Often these lipid deposits are not limited to the skin but are found throughout the body in bones, the heart, blood vessels, liver, and other organs.



The formation of xanthomas may indicate an underlying disease, usually related to abnormal metabolism of lipids, including cholesterol. Abnormally high levels of blood lipids may be found in diabetes mellitus (xanthoma diabeticorum), in diseases of the liver, kidney, and thyroid gland, and in several hereditary metabolic diseases. The excessive lipids carried in the blood may then be deposited as xanthomas. Treatment includes surgery, application of acids directly to the lipid deposits, and management of the disease that causes them.
Legs of a person homozygous for familial hypercholesterolemia, showing multiple xanthomas. From Mueller and Young, 2001.
diabetic xanthoma an eruptive xanthoma associated with diabetes mellitus; when the diabetes is brought under control, the skin lesions disappear.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

xan·tho·ma

(zan-thō'mă),
A yellow nodule or plaque, especially of the skin, composed of lipid-laden histiocytes.
[G. xantho-, blond + G. -oma, tumor]
Farlex Partner Medical Dictionary © Farlex 2012

xanthoma

(zăn-thō′mə)
n. pl. xantho·mas or xantho·mata (-mə-tə)
A yellowish-orange, lipid-filled nodule or papule in the skin, often on an eyelid or over a joint.

xan·thom′a·tous (-thŏm′ə-təs) adj.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

xanthoma

Fatty skin growth Dermatology A yellow-orange lipid-filled papule or plaque located on the skin or tendons, which is common in the general population and Pts with DM, and may be ↑ in various 'lipid disorders–eg, lipoprotein lipase deficiency, abetalipoproteinemia, hypercholesterolemia, hypertriglyceridemia
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

xan·tho·ma

(zan-thō'mă)
A yellow nodule or plaque, especially of the skin, composed of lipid-laden histiocytes.
[G. xantho-, blond + G. -oma, tumor]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

xanthoma

A yellowish or orange mass of fat-filled cells occurring in the skin of people with various disorders of fat metabolism. Also known as generalized XANTHELASMA.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

xanthelasma 

A cutaneous deposition of lipid material that appears in the skin of the eyelids, most commonly near the inner canthi. It appears as a yellowish, slightly elevated area. It is a benign and chronic condition that occurs primarily in the elderly. It may be associated with raised blood cholesterol, high-density lipoprotein and triglyceride levels, leading to heart disease or diabetes. Syn. xanthoma; xanthelasma palpebrarum; xanthoma palpebrarum. See corneal arcus; Hollenhorst's plaque.
Millodot: Dictionary of Optometry and Visual Science, 7th edition. © 2009 Butterworth-Heinemann

xan·tho·ma

(zan-thō'mă)
Yellow nodule or plaque, especially dermatologic, composed of lipid-laden histiocytes.
[G. xantho-, blond + G. -oma, tumor]
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Vegas (verruciform genital-associated) xanthoma: a comprehensive literature review.
* Xanthoma disseminatum is an extremely rare, but benign, disorder of non-Langerhans cell origin.
Unique presentation of normolipaemic cutaneous xanthoma in a cat.
Wang et al., "Oral verruciform xanthoma: a clinicopathologic study of 15 cases," Journal of the Formosan Medical Association, vol.
In epithelial lesions, the frequency of occurrence was in the following order: glycogenic acanthosis, heterotopic gastric mucosa, squamous papilloma, hyperplastic polyp, ectopic sebaceous gland, and xanthoma. In subepithelial lesions, the order was as follows: hemangioma, leiomyoma, dysphagia aortica, and granular cell tumor [15].
Hubbell, "Sclerosing hemangioma (histiocytoma, xanthoma) of the lung," Cancer, vol.
FNAC of tuberous xanthoma yielded scant aspirate, with low cellular smears showing scattered spindle shaped cells.
The lower leg and feet should be inspected for ulcers, fissure's, callous, and areas of yellowish pigmentation due to the deposit of lipids (xanthoma) (Dieter, R.S.
In another study, both xanthoma tissue-modified LDL (x-LDL) and copper sulfate oxidized-LDL (Cu-LDL) were able to induce the adhesion of monocyte leukemic cell lines (U937) to human dermal microvascular endothelial cells (HDMEC), but this was related to upregulation in the expression of different adhesion molecules depending on the kind of oxLDL.
It is widely assumed that the Human papilloma Virus (HPV) is an etiologic factor of papillomas.1 The lesion may look wart-like or cauliflower like and may be difficult to differentiate clinically from verruca vul- garis, condyloma acuminatum, verruciform xanthoma or focal epithelial hyperplasia.2,3
Old, overweight and physically inactive people, any condition that crowds or reduces the capacity of the carpal tunnel may initiate the symptoms; a misaligned Colles fracture and edema from infection or trauma, post traumatic arthritis or tumourous conditions such as a ganglion, lipoma or xanthoma are among the most common causes of Carpal Tunnel Syndrome.
A There are various possible causes of a lump like this, including warty growths, an abscess, a xanthoma (fatty mass with thickened skin) or a tumour.