xanthogranulomatous inflammation

xanthogranulomatous inflammation

A nonspecific term for a disparate group of conditions that share a common pathology of a wedge-shaped infiltrate of lipid-laden S-100-negative histiocytes/macrophages accompanied by mixed inflammatory cells, including lymphocytes, plasma cells, neutrophils and eosinophils, with sparing of the epidermis.

Examples
Fat necrosis, lipophages, xanthoma, xanthogranuloma, non-Langerhans cell histiocytosis, xanthogranulomatous necrobiosis, tumours (e.g., benign fibrous histiocytoma, giant cell tumour), verruciform xanthoma.

DiffDx
Tuberculosis, fungal infections.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Benign tumors, spread of malignance from the endocervix, and endometrial cancer are usually associated with pyometra, and xanthogranulomatous inflammation is also reported in surgical specimens (16, 17).
Xanthogranulomatous inflammation of myometrium with uterine perforation.
Xanthogranulomatous inflammation is well known in the kidney and gallbladder and has been described in many anatomic sites, such as the mandible, retroperitoneum, third ventricle, choroid plexus, orbit, vagina, lung, stomach, pericardium, and ovary [4].
Brucker, "Dramatic Enlargement of the Prostate due to Xanthogranulomatous Inflammation," LUTS: Lower Urinary Tract Symptoms, vol.
Xanthogranulomatous inflammation is a rare form of chronic inflammation that can involve various organs but is most commonly reported in the kidney and gallbladder.
Kapoor, "Xanthogranulomatous inflammation stricture of extrahepatic biliary tract: presentation and surgical management," Journal of Gastrointestinal Surgery, vol.
Both lesions had xanthogranulomatous inflammation with numerous foamy histiocytes and extensive fibrosis extending into the muscularis propria.
Xanthogranulomatous inflammation is a benign condition characterized by the presence of multinucleated giant cells, chronic inflammatory cells and lipid-laden macrophages known as xanthoma cells.[sup.1] Xanthogranulomatous pyelonephritis is not uncommon.
In avian medicine, the syndromes of xanthoma, xanthomatosis, and xanthogranulomatous inflammation have not been consistently defined or separated (Table 1).
The predominant finding in the excised mass obtained from our patient was xanthogranulomatous inflammation, although the mass did contain small areas of residual Warthin's tumor.
Malacoplakia is an unusual yet well-documented form of chronic xanthogranulomatous inflammation. The pathogenesis of malacoplakia has not been fully elucidated, but it is generally considered to be related to an acquired defect in macrophage phagocytic bactericidal activity against bacterial pathogens, especially E coli.
The presence of a large number of lipid-containing macrophages with an admixture of lymphocytes, plasma cells, and neutrophils is characteristic of xanthogranulomatous inflammation. Multinucleated giant cells may be present.