In the veterinary literature, inconsistent terminology, including xanthoma, xanthomatosis, and xanthogranuloma
have all been used interchangeably when referring to this disease process.
(43,44) In younger patients, disseminated juvenile xanthogranuloma
and Langerhans cell histiocytosis may be considered.
Chloe Mullan, from Accrington, has undergone months of 'gruelling treatment' to fight juvenile xanthogranuloma
(JXG), which affects only one in every 10 million children.
, characterized by yellow-brown asymptomatic papules and nodules, develops most often within the first year of life, but the lesions usually resolve spontaneously by school age, he added.
Among the seven articles in the first issue were: "Ossifying Enchondroma of the Head of the Humerus" by Philip Barack, "Tuberculosis of the Ischial Tuberosity: Partial Resection of the Ischium" by Henry Milch, "Xanthogranuloma
of the Knee Joint" by Milton Friedman and Arthur Ginzler, and "Osteochondritis Dissecans of the Femoral Head" by Aaron M.
Other etiologies included tumors with secondary pericardial invasion in two patients: one due to mediastinal B- cell lymphoma and one due to xanthogranuloma
of the epicardium who was previously reported .
Darier's sign is not always demonstrable, especially in those with a long history of the disorder and is not 100% specific for mastocytosis, since it has also been described rarely in juvenile xanthogranuloma
and acute lymphoblastic leukemia of neonates.12,13 Lesions may blister in infancy or childhood and may be the presenting feature but heal without scarring.
Since its first observation in the lung in 1939, many different terms have been coined to describe IPT, such as inflammatory myofibroblastic tumor, plasma cell granuloma, inflammatory myofibrohistiocytic proliferation, inflammatory fibrosarcoma, xanthoma, xanthogranuloma
, fibroxanthoma, histiocytoma, xanthomatous pseudotumor, plasmocytoma, and solitary mast cell granuloma, indicating the complex and diverse nature of this entity (1).
Immunohistochemical staining showed strong positive of CD68, but negative of S100 and SMA [Figure 1]h-[Figure 1]j, which was consistent with a diagnosis of xanthogranuloma
of the sellar region.
A biopsy from the anterior abdominal wall muscle showed infiltration with xanthomatous histiocytes and Touton multinucleated giant cells, positive for CD68 and negative for S100 and CD1a indicating xanthogranuloma
In systemic histiocytic disorders, such as juvenile xanthogranuloma
, xanthoma disseminatum, Erdheim-Chester disease, and dendrocytomas, FXIII-A, along with other markers (e.g., S100, CD1a, CD68, fascin, CD207, and CD35), is also used as a key diagnostic tool [49-51].