(Provectus or the Company) is a clinical-stage biotechnology company developing a new class of drugs based on an entirely- and wholly-owned family of chemical small molecules called halogenated xanthenes
. Information about the Company's clinical trials can be found at the NIH registry, www.clinicaltrials.gov.
Given the strong electron-withdrawing nature of N[O.sub.2] and the electron-donating character of rosamines, the most plausible mechanism for the changes induced on the rosamines would be an oxidation through a charge transfer process from the electron-rich xanthene
group to the oxidant gas.
Therefore, the photodynamic efficiency of four xanthene
dyes (Rose Bengal, erythrosin B, eosin Y, and fluorescein) was determined in the present study by comparing their medium inhibitory concentration ([IC.sub.50]) values in HEp2 cells, their photodynamic activity using uric acid as a chemical dosimeter, and their octanol-buffer partition coefficient (log P).
The high quantum yield of fluorescence was reported for laser organic dyes (xanthenes
, oxazines, 7-aminocoumarins) .
dyes/amine as photoinitiators of radical polymerization: a comparative and photochemical study in aqueous medium," Polymer, vol.
Several methods have been reported for the synthesis of xanthenes
which includes by using poly(4-vinyl pyridinium) perchlorate , task specific acidic ionic liquid [NMP] [H.sub.2]S[O.sub.4] , nano silica phosphoric acid , HCl[O.sub.4]-Si[O.sub.2] , proline triflate in water , Iodine , In[Cl.sub.3] , Sr[(OTf).sub.2]  and p-TSA .
In living organisms free radicals are produced as a result of the normal metabolic process and also free radical chain reactions normally occur as respiratory chain reaction in the mitochondria through xanthene
oxidase activity liver mixed function oxidases atmospheric pollutants and from the transitional metal catalysts xenobiotics and drugs.
A new xanthene
(2,6-dihydroxy-7-methoxy-3H-xanthen-3one) was isolated from the methanolic extract of Desmostachya bipinnata, which was found to inhibit signal transducer and activator of transcription 3 (STAT3) and lowdensity lipoprotein-oxidation .
Seybold, "Solvent dependence of the fluorescence lifetimes of xanthene
dyes," Photochemistry and Photobiology, vol.
Excimer emission and energy transfer in cofacial boradia-zaindacence (BODIPY) dimmers built on a xanthene
1 (1 g/l xanthene
in sodium azide-preserved buffer) for 10 seconds and then in solution No.
Polysaccharides such as carrageenan, pullulan, xanthene
gellan gum, guar gum and gum arabic can be used to form a paste without the separation of components of alginate paste [30, 31].