xamoterol


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xamoterol

A now-withdrawn beta-adrenergic stimulant drug that was used to treat mild degrees of HEART FAILURE. The drug has been used as a stimulant by athletes to try to improve performance and is on the International Olympic Committee's list of banned substances. A brand name was Corwin.
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Differential effects of xamoterol and verapamil on ventricular rate regulation in patients with chronic atrial fibrillation.
Placebo controlled trial of xamoterol versus digoxin in chronic atrial fibrillation.
Xamoterol improves the control of chronic atrial fibrillation in elderly patients.
The data regarding xamoterol were mixed.[20-23] Celiprolol[26] and labetalol were no more efficacious than placebo at rest.
Xamoterol is a selective [B.sub.1]-adrenergic partial agonist.
After baseline measurements, each patient received, in double-blind randomized order, treatment with xamoterol 200mg b.d.
Three patients withdrew before starting the study medication, one further patient developed diarrhoea within 1 week of starting treatment with digoxin plus xamoterol, and one patient was withdrawn because of worsening heart failure when taking xamoterol alone, having tolerated xamoterol with digoxin.
Single treatment with xamoterol caused an increase in heart rate over the whole of the 24-h period.
Thomas, "Xamoterol impairs hippocampus-dependent emotional memory retrieval via Gi/o-coupled beta2-adrenergic signaling," Learning & Memory, vol.
Thomas, "Xamoterol impairs hippocampus-dependent emotional memory retrieval via [G.sub.i/o]-coupled [[beta].sub.2]-adrenergic signaling," Learning & Memory, vol.
Cells were grown in high glucose medium until confluent, serum starved for 18-24 hours, followed by treatment with a beta-1-adrenergic receptor agonist, xamoterol. Cell culture lysates were collected at 15, 30, and 45 minutes after stimulation, along with not-treated controls.