writhing number

writh·ing num·ber

the number of times a DNA duplex axis crosses over itself in space.
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EOPPgfl (20, 30, and 60 mg/kg) and indomethacin (10 mg/kg) significantly reduced (P<0.05, ANOVA, Dunn test) writhing number from 51.9 [+ or -] 1.62 counts (n=10) (control value) to 35.2 [+ or -] 2.64 (n=10), 25.9 [+ or -] 2.32 (n=10), 31.2 [+ or -] 5.8, and 7.5 [+ or -] 2.8 counts (n=8), respectively (Figure 1A).
The writhing number describes the supertwisting or supercoiling of the helix in space.
There was no significant difference between diclofenac (10 mg/kg body wt.) and the extracts in reduction of writhing numbers. Naloxone (2 mg/kg body wt., i.v.) pretreatment after i.p.