in Marfan syndrome, appreciable overlap of the thumb and fifth finger when the wrist is gripped with the opposite hand.
wrist signRheumatology A finding in Pts with Marfan and other heritable connective tissue disorders characterized by thinned distal extremities; the WS is positive if the distal phalanges of the thumb and 5th finger overlap when encircling the opposite wrist. See Marfan syndrome.
wrist sign(rist sīn)
In Marfan syndrome, when the wrist is gripped with the opposite hand, the thumb and fifth finger overlap appreciably.