ACE

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angiotensin

 (ACE) [an″je-o-ten´sin]
a vasoconstrictive substance formed in the blood when renin is released from the juxtaglomerular apparatus in the kidney. The enzymatic action of renin acts on angiotensinogen to form the decapeptide angiotensin I, which is relatively inactive. It in turn is acted upon by peptidases (converting enzymes), chiefly in the lungs, to form the octapeptide angiotensin II, a powerful vasopressor and a stimulator of aldosterone secretion by the adrenal cortex. By its vasopressor action, it raises blood pressure and diminishes fluid loss in the kidney by restricting blood flow. Angiotensin II is hydrolyzed in various tissues to form heptapeptide angiotensin III, which has less vasopressor activity but more effect on the adrenal cortex.
angiotensin-converting enzyme (ACE) an enzyme of the hydrolase class that catalyzes cleavage of a dipeptide from the C-terminal end of angiotensin I to form activated angiotensin II; called also peptidyl-dipeptidase A.
angiotensin-converting enzyme inhibitors competitive inhibitors of angiotensin-converting enzyme, which converts angiotensin I to angiotensin II and inactivates bradykinin. ACE inhibitors, such as captopril, are antagonists of the renin-angiotensin-aldosterone system and potentiators of the kinin system and are used for treatment of hypertension, usually in conjunction with a diuretic. They are also used as vasodilators in the treatment of congestive heart failure.

ACE

ACE

(1) Abciximab & Carbostent Evaluation in Acute Myocardial Infarction. A trial comparing outcomes of carbon-coated stenting of an infarct-related artery with and without abciximab.
Primary endpoint 30-day MACE (major acute coronary events)
Conclusion Abciximab + IRA stenting may be a viable reperfusion strategy in patients with acute myocardial infarction undergoing primary percutaneous revascularization.
(2) ASA & Carotid Endarterectomy. A trial comparing high- and low-dose aspirin to reduce the risk of stroke in patients undergoing carotid endarterectomy.
Primary endpoints 30-day MACE (major acute coronary events), stroke
Conclusion Low-dose (80, 325 mg) ASA patients did better

ACE

Angiotensin-converting enzyme, see there. Cf ACE inhibitors, also
1. Acute Care for Elderly.
2. Adriamycin, cyclophosphamide, etoposide.
3. Alcohol, chloroform, ether–obsolete anesthetic cocktail.
4. American College of Epidemiology.

ACE

Abbreviation for angiotensin-converting enzyme.

ACE

See ANGIOTENSIN-CONVERTING ENZYME.
References in periodicals archive ?
But the Italians, playing with passion and no little skill, came within an ace of beating us.
RHYL maintained their unbeaten record at the top of the Huws Gray Alliance yesterday - but only just as Holyhead came within an ace of causing a major upset.
The fans' Player of the Year has taken to a change in formation and came within an ace of getting Wolves an equaliser against Chelsea.
The judge said the four had come within an ace of going straight to custody but had been spared because of their relative youth.
CONFIDENT Richard Hughes fancied his chances of a Newmarket four-timer and he came within an ace of achieving it.
TRANMERE extended their unbeaten run to eight last Saturday at Bristol Rovers and despite having to play half the game with 10 men came within an ace of taking all three points.
Clare recorded a rare McGrath Cup success with a win over Limerick last Sunday while Paul Bealin's side came within an ace of knocking Dublin out of the O'Byrne Cup.
They came within an ace of producing an amazing recovery against Ireland, but in the end had to settle for a share of the honours.
I came within an ace of winning it as a jockey on Garrison Savannah and we were also second with Smarty.
Pirelli, the sole supplier of tyres for the series, have made a massive grip breakthrough - and tests last week in Qatar put WSB lap times within an ace of the much more powerful MotoGP machines.
Julio Arca says Championship top two Wigan and Ipswich are starting to feel the heat as Sunderland moved to within an ace of the automatic promotion slots at the weekend, (writes James Hunter).
However back in 2002 Lovering was part of the Ayr United side that came within an ace of toppling Rangers in the CIS Cup Final.

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