windup

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windup

Central sensitization, neuroplasticity Anesthesiology A physiologic ↑ sensitization of excitable neurons, coupled to a ↓ threshold for peripheral afferent pain terminals; windup may be mediated by excitatory amino acid neurotransmitters and neuropeptides; NMDA receptor inhibitors prevent 'windup' and may play a central role in managing chronic pain. See NMDA receptor antagonist, Preemptive analgesia. Cf Multimodality pain control.
References in periodicals archive ?
"The danger with wind-ups as opposed to self-help is that you can start to believe your own hype and put the tools away where proper focus and concentration are concerned.
There was confusion in the camp yesterday about whether the game was on or off after a string of wind-ups.
Your average Scottish dressing-room has more jokers than a comics' convention, with wind-ups ranging from harmless fun to downright cruelty.
It's not f***ing funny'." The stunt, which has now been axed from the show, was intended for the ace's All Star Wind-Ups - a follow up to Rio's World Cup Wind-Ups.
The appearance of Rio led fans to wonder if Sturridge had fallen foul of a prank by the Reds legend, who is known for setting up stars as part of an ITV show called Rio Ferdinand's World Cup Wind-Ups.
FRIDAY NIGHT DINNER Channel 4, 10pm Robert Popper's award-winning comedy populated by the accomplished cast of Simon Bird, Tom Rosenthal, Tamsin Greig and Paul Ritter continues as brothers Adam and Jonny once again return to their parents' house for their traditional Friday night dinner of soup, chicken and crimble crumble - plus massive sideorders of wind-ups and bickering.
On the menu for the first of the new run is soup, chicken and crimble crumble - plus large sideorders of wind-ups and lots of domestic bickering.
The Newcastle defender is usually the main man when it comes to wind-ups in the Toon dressing room.
Euro Wind-Ups will see the stars play jokes on other players while hidden cameras capture the action in a You've Been Framed style show.
'Euro Wind-Ups' will see the stars play jokes on other players while hidden cameras capture the action in a 'You've Been Framed' style show.
If he comes out faster than usual maybe the wind-ups will have worked WayneRooney - David haye is wearing the new England away shirt in the ring tomorrow, good luck for the fight @MrDavidHaye fizzer18 (Phil Neville) - Off to the gym- running session today-10x20m 10x30m sprints followed by 1x20m-5secs rest 1x40m-10secs rest 1x60m x10 (sprint) LFC - Congratulations to our boss @kennethdalglish who today received a doctorate from the University of Ulster!