windup

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windup

Central sensitization, neuroplasticity Anesthesiology A physiologic ↑ sensitization of excitable neurons, coupled to a ↓ threshold for peripheral afferent pain terminals; windup may be mediated by excitatory amino acid neurotransmitters and neuropeptides; NMDA receptor inhibitors prevent 'windup' and may play a central role in managing chronic pain. See NMDA receptor antagonist, Preemptive analgesia. Cf Multimodality pain control.
References in periodicals archive ?
This is an excellent fit for Mercer Canada, as it enhances our own successful business in pension wind-ups.
The danger with wind-ups as opposed to self-help is that you can start to believe your own hype and put the tools away where proper focus and concentration are concerned.
Your average Scottish dressing-room has more jokers than a comics' convention, with wind-ups ranging from harmless fun to downright cruelty.
The stunt, which has now been axed from the show, was intended for the ace's All Star Wind-Ups - a follow up to Rio's World Cup Wind-Ups.
It is believed Man United's Ferdinand, 33, may be lead mischief-maker as he starred in a similar show called Rio's World Cup Wind-Ups in 2006.
The Australians appear to have started the Ashes wind-ups early by claiming that cricket, the most English of sports, is actually a Belgian invention.
The striker revealed the banter and the wind-ups with his old team-mates had already started prior to his reunion but insisted he was not taking the game lightly.
Users can send personalised Buzzcasts, including cheer-ups, wind-ups, wake-ups, chat-ups and birthday, congratulations and good luck messages; along with Buzztones, including original comic video ringtones, reminders and alarm tones.
Normally the nerves and the wind-ups start a good couple of weeks in advance, but this Goodison encounter seems to have almost crept up on us.
Rio, 27, impressed telly chiefs with a one-off World Cup wind-ups show in May when he duped stars like Wayne Rooney and Gary Neville.
Seeing all those pictures of Liverpool players dressed as superheroes yesterday made me wonder if Rio Ferdinand was having another one of his wind-ups, telling Rafa Benitez that Uefa were replacing the draw with a fancy-dress competition.
The company can coordinate and control the complete calender line, including all feed mills and/or extruder systems, calender and line speeds and ratios, temperatures, tensions, let-offs and wind-ups.